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Literature summary for 1.14.18.1 extracted from

  • Ng, L.T.; Ko, H.H.; Lu, T.M.
    Potential antioxidants and tyrosinase inhibitors from synthetic polyphenolic deoxybenzoins (2009), Bioorg. Med. Chem., 17, 4360-4366.
    View publication on PubMed
Search for more literature for 1.14.18.1

Inhibitors

Inhibitors Comment Organism Structure
2,3,4'-trihydroxy-4-methoxydeoxybenzoin displays stable and significant inhibitory effect on tyrosinase activity Agaricus bisporus
2,3,4,4'-tetrahydroxydeoxybenzoin
-
 Agaricus bisporus
2,3,4-trihydroxy-3',4'-dimethoxydeoxybenzoin
-
 Agaricus bisporus
2,3,4-trihydroxy-4'-methoxydeoxybenzoin
-
 Agaricus bisporus
2,4,4',6-tetrahydroxydeoxybenzoin
-
 Agaricus bisporus
2,4,4'-trihydroxydeoxybenzoin
-
 Agaricus bisporus
2,4,5-trihydroxy-4'-methoxydeoxybenzoin
-
 Agaricus bisporus
2,4,6-trihydroxy-4'-methoxydeoxybenzoin
-
 Agaricus bisporus
2,4-dihydroxy-3',4'-dimethoxydeoxybenzoin
-
 Agaricus bisporus
2,4-dihydroxy-4'-methoxydeoxybenzoin
-
 Agaricus bisporus
3,4-dihydroxy-4'-methoxydeoxybenzoin
-
 Agaricus bisporus
kojic acid
-
 Agaricus bisporus

Organism

Organism UniProt Comment Textmining
Agaricus bisporus
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-tyrosine + L-dopa + O2
-
 Agaricus bisporus L-dopa + dopaquinone + H2O
-
 ?

Synonyms

Synonyms Comment Organism
tyrosinase
-
 Agaricus bisporus

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.0431
-
 at incubation interval of 1.5 h Agaricus bisporus 2,3,4'-trihydroxy-4-methoxydeoxybenzoin
0.04337
-
 at incubation interval of 0.5 h Agaricus bisporus 2,3,4'-trihydroxy-4-methoxydeoxybenzoin
0.0461
-
 at incubation interval of 2.5 h Agaricus bisporus 2,3,4'-trihydroxy-4-methoxydeoxybenzoin
0.07105
-
 at incubation interval of 0.5 h Agaricus bisporus 2,4,6-trihydroxy-4'-methoxydeoxybenzoin
0.0788
-
 at incubation interval of 0.5 h Agaricus bisporus 2,4-dihydroxy-4'-methoxydeoxybenzoin
0.08435
-
 at incubation interval of 0.5 h Agaricus bisporus 2,4,5-trihydroxy-4'-methoxydeoxybenzoin
0.1121
-
 at incubation interval of 0.5 h Agaricus bisporus 2,4-dihydroxy-3',4'-dimethoxydeoxybenzoin
0.1328
-
 at incubation interval of 0.5 h Agaricus bisporus kojic acid
0.1359
-
 at incubation interval of 1.5 h Agaricus bisporus 2,4,4'-trihydroxydeoxybenzoin
0.1442
-
 at incubation interval of 1.5 h Agaricus bisporus 2,4,5-trihydroxy-4'-methoxydeoxybenzoin
0.1604
-
 at incubation interval of 1.5 h Agaricus bisporus 2,4-dihydroxy-4'-methoxydeoxybenzoin
0.168
-
 at incubation interval of 1.5 h Agaricus bisporus 3,4-dihydroxy-4'-methoxydeoxybenzoin
0.1724
-
 at incubation interval of 2.5 h Agaricus bisporus 2,4,4'-trihydroxydeoxybenzoin
0.1777
-
 at incubation interval of 2.5 h Agaricus bisporus 3,4-dihydroxy-4'-methoxydeoxybenzoin
0.1785
-
 at incubation interval of 0.5 h Agaricus bisporus 2,4,4'-trihydroxydeoxybenzoin
0.1814
-
 at incubation interval of 2.5 h Agaricus bisporus 2,4-dihydroxy-4'-methoxydeoxybenzoin
0.1974
-
 at incubation interval of 2.5 h Agaricus bisporus 2,4,5-trihydroxy-4'-methoxydeoxybenzoin
0.2033
-
 at incubation interval of 1.5 h Agaricus bisporus 2,3,4-trihydroxy-4'-methoxydeoxybenzoin
0.2091
-
 at incubation interval of 1.5 h Agaricus bisporus 2,4-dihydroxy-3',4'-dimethoxydeoxybenzoin
0.2119
-
 at incubation interval of 2.5 h Agaricus bisporus 2,3,4-trihydroxy-4'-methoxydeoxybenzoin
0.2139
-
 at incubation interval of 1.5 h Agaricus bisporus 2,4,6-trihydroxy-4'-methoxydeoxybenzoin
0.2251
-
 at incubation interval of 1.5 h Agaricus bisporus kojic acid
0.2302
-
 at incubation interval of 2.5 h Agaricus bisporus 2,4,6-trihydroxy-4'-methoxydeoxybenzoin
0.2397
-
 at incubation interval of 2.5 h Agaricus bisporus 2,4-dihydroxy-3',4'-dimethoxydeoxybenzoin
0.2613
-
 at incubation interval of 2.5 h Agaricus bisporus 2,4,4',6-tetrahydroxydeoxybenzoin
0.3
-
 IC50 above 0.3 mM, at incubation interval of 0.5 h Agaricus bisporus 2,3,4,4'-tetrahydroxydeoxybenzoin
0.3
-
 IC50 above 0.3 mM, at incubation interval of 0.5 h Agaricus bisporus 2,3,4-trihydroxy-4'-methoxydeoxybenzoin
0.3
-
 IC50 above 0.3 mM, at incubation interval of 0.5 h Agaricus bisporus 3,4-dihydroxy-4'-methoxydeoxybenzoin
0.3
-
 IC50 above 0.3 mM, at incubation interval of 0.5 h Agaricus bisporus 2,4,4',6-tetrahydroxydeoxybenzoin
0.3
-
 IC50 above 0.3 mM, at incubation interval of 1.5 h Agaricus bisporus 2,3,4,4'-tetrahydroxydeoxybenzoin
0.3
-
 IC50 above 0.3 mM, at incubation interval of 1.5 h Agaricus bisporus 2,4,4',6-tetrahydroxydeoxybenzoin
0.4383
-
 at incubation interval of 2.5 h Agaricus bisporus kojic acid
0.5
-
 IC50 above 0.5 mM, at incubation interval of 2.5 h Agaricus bisporus 2,3,4,4'-tetrahydroxydeoxybenzoin