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Literature summary for 1.14.18.1 extracted from

  • Baek, Y.S.; Ryu, Y.B.; Curtis-Long, M.J.; Ha, T.J.; Rengasamy, R.; Yang, M.S.; Park, K.H.
    Tyrosinase inhibitory effects of 1,3-diphenylpropanes from Broussonetia kazinoki (2009), Bioorg. Med. Chem., 17, 35-41.
    View publication on PubMed
Search for more literature for 1.14.18.1

Inhibitors

Inhibitors Comment Organism Structure
broussonin C competitive inhibition Agaricus bisporus
kazinol C competitive inhibition Agaricus bisporus
kazinol D
-
 Agaricus bisporus
kazinol F competitive inhibition Agaricus bisporus
kazinol S competitive inhibition, i.e. 5'-(2-methylbut-3-en-2-yl)-6''-(3-methylbut-2-enyl)-5''-(2,3-epoxy-3-methylbytyl)-2',4',3'',4''-tetrahydroxy diphenylpropane Agaricus bisporus
kazinol T i.e. 5'-(2-methylbut-3-en-2-yl)-6''-(3-methylbut-2-enyl)-4'',5''-[(2-(1-hydroxy-1-methylethyl)]-dihydrofuranyl)-2',4',3''-trihydroxy diphenylpropane Agaricus bisporus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.18
-
 L-tyrosine in 0.25 M phosphate buffer (pH 6.8), at 30°C Agaricus bisporus
0.36
-
 L-Dopa in 0.25 M phosphate buffer (pH 6.8), at 30°C Agaricus bisporus

Organism

Organism UniProt Comment Textmining
Agaricus bisporus
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-tyrosine + L-dopa + O2
-
 Agaricus bisporus L-dopa + dopaquinone + H2O
-
 ?

Synonyms

Synonyms Comment Organism
polyphenol oxidase
-
 Agaricus bisporus
PPO
-
 Agaricus bisporus
tyrosinase
-
 Agaricus bisporus

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.00043
-
 using L-tyrosine as substrate, in 0.25 M phosphate buffer (pH 6.8), at 30°C Agaricus bisporus broussonin C
0.00057
-
 using L-DOPA as substrate, in 0.25 M phosphate buffer (pH 6.8), at 30°C Agaricus bisporus broussonin C
0.00096
-
 using L-tyrosine as substrate, using L-tyrosine as substrate, in 0.25 M phosphate buffer (pH 6.8), at 30°C Agaricus bisporus kazinol F
0.0017
-
 using L-DOPA as substrate, using L-tyrosine as substrate, in 0.25 M phosphate buffer (pH 6.8), at 30°C Agaricus bisporus kazinol F
0.0155
-
 using L-tyrosine as substrate, in 0.25 M phosphate buffer (pH 6.8), at 30°C Agaricus bisporus kazinol C
0.0179
-
 using L-tyrosine as substrate, in 0.25 M phosphate buffer (pH 6.8), at 30°C Agaricus bisporus kazinol S
0.0228
-
 using L-DOPA as substrate, in 0.25 M phosphate buffer (pH 6.8), at 30°C Agaricus bisporus kazinol C
0.0269
-
 using L-DOPA as substrate, in 0.25 M phosphate buffer (pH 6.8), at 30°C Agaricus bisporus kazinol S
0.1031
-
 using L-tyrosine as substrate, in 0.25 M phosphate buffer (pH 6.8), at 30°C Agaricus bisporus kazinol T
0.1647
-
 using L-tyrosine as substrate, in 0.25 M phosphate buffer (pH 6.8), at 30°C Agaricus bisporus kazinol D
0.2
-
 IC50 above 0.2 mM, using L-DOPA as substrate, in 0.25 M phosphate buffer (pH 6.8), at 30°C Agaricus bisporus kazinol D
0.2
-
 IC50 above 0.2 mM, using L-DOPA as substrate, in 0.25 M phosphate buffer (pH 6.8), at 30°C Agaricus bisporus kazinol T