Activating Compound | Comment | Organism | Structure |
---|---|---|---|
2,3,5,4'-tetrahydroxystilbene-2-O-beta-D-glucoside | THSG, tyrosinase activator isolated from Radix Polygoni multiflori | Agaricus bisporus | |
2,3,5,4'-tetrahydroxystilbene-2-O-beta-D-glucoside | THSG, tyrosinase activator isolated from Radix Polygoni multiflori. It significantly increases the activity of murine tyrosinase and stimulates melanin biosynthesis in B16 melanoma cells. THSG is found to be non-cytotoxic to B16 melanoma cells at a concentration of 0.1-12.5 microg/ml | Mus musculus | |
chrysophanol | anthraquinone | Mus musculus | |
chrysophanol | anthraquinone, slightly activates tyrosinase | Agaricus bisporus | |
emodin | anthraquinone | Mus musculus | |
emodin | anthraquinone, slightly activates tyrosinase | Agaricus bisporus | |
gallic acid | - |
Mus musculus | |
gallic acid | - |
Agaricus bisporus | |
physcion | anthraquinone | Mus musculus | |
physcion | anthraquinone, slightly activates tyrosinase | Agaricus bisporus |
Application | Comment | Organism |
---|---|---|
drug development | activators of tyrosinase with stimulatory effects on melanogenesis are beneficial for the treatment of hypopigmentation diseases. 2,3,5,4'-tetrahydroxystilbene-2-O-beta-D-glucoside is a potent tyrosinase activator and stimulator of melanogenesis with potential for the treatment of hypopigmentation disease | Mus musculus |
drug development | activators of tyrosinase with stimulatory effects on melanogenesis are beneficial for the treatment of hypopigmentation diseases. THSG is a potent tyrosinase activator and stimulator of melanogenesis with potential for the treatment of hypopigmentation disease | Agaricus bisporus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Agaricus bisporus | - |
- |
- |
Mus musculus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
B-16 cell | - |
Mus musculus | - |
commercial preparation | - |
Agaricus bisporus | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
additional information | - |
for the mushroom tyrosinase activity assay, mushroom tyrosinase with 100 U/ml is used | Agaricus bisporus |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-3,4-dihydroxyphenylalanine + 1/2 O2 | - |
Mus musculus | L-dopaquinone + H2O | - |
? | |
L-dopa + 1/2 O2 | - |
Agaricus bisporus | L-dopachrome + H2O | - |
? |
Synonyms | Comment | Organism |
---|---|---|
murine tyrosinase | from cultured B16 cells | Mus musculus |
tyrosinase | - |
Mus musculus |
tyrosinase | - |
Agaricus bisporus |