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Literature summary for 1.14.18.1 extracted from

  • Zheng, Z.P.; Cheng, K.W.; To, J.T.; Li, H.; Wang, M.
    Isolation of tyrosinase inhibitors from Artocarpus heterophyllus and use of its extract as antibrowning agent (2008), Mol. Nutr. Food Res., 52, 1530-1538.
    View publication on PubMed

Application

Application Comment Organism
food industry inhibitors have good potential as antibrowning agents to be applied in real food systems Agaricus bisporus

Inhibitors

Inhibitors Comment Organism Structure
7-(2,4-dihydroxyphenyl)-4-hydroxy-2-(2-hydroxypropan-2-yl)-2,3-dihydrofuro(3,2-g)chromen-5-one artocarpfuranol, isolated from the wood of Artocarpus heterophyllus, strong mushroom tyrosinase inhibitory activity Agaricus bisporus
artocarpanone isolated from the wood of Artocarpus heterophyllus, strong mushroom tyrosinase inhibitory activity Agaricus bisporus
artocarpesin isolated from the wood of Artocarpus heterophyllus, strong mushroom tyrosinase inhibitory activity Agaricus bisporus
artocarpetin isolated from the wood of Artocarpus heterophyllus Agaricus bisporus
artocarpin isolated from the wood of Artocarpus heterophyllus Agaricus bisporus
brosimone I isolated from the wood of Artocarpus heterophyllus Agaricus bisporus
carpachromene isolated from the wood of Artocarpus heterophyllus Agaricus bisporus
cudraflavone B isolated from the wood of Artocarpus heterophyllus Agaricus bisporus
cyanomaclurin isolated from the wood of Artocarpus heterophyllus Agaricus bisporus
cycloartocarpesin isolated from the wood of Artocarpus heterophyllus Agaricus bisporus
cycloartocarpin isolated from the wood of Artocarpus heterophyllus Agaricus bisporus
dihydromorin isolated from the wood of Artocarpus heterophyllus, strong mushroom tyrosinase inhibitory activity Agaricus bisporus
isoartocarpesin isolated from the wood of Artocarpus heterophyllus, strong mushroom tyrosinase inhibitory activity Agaricus bisporus
kojic acid well-known tyrosinase inhibitor Agaricus bisporus
additional information antibrowning effects of Artocarpus heterophyllus extracts on fresh-cut apple slices tested Agaricus bisporus
norartocarpetin isolated from the wood of Artocarpus heterophyllus, strong mushroom tyrosinase inhibitory activity Agaricus bisporus
steppogenin isolated from the wood of Artocarpus heterophyllus, strong mushroom tyrosinase inhibitory activity Agaricus bisporus

Organism

Organism UniProt Comment Textmining
Agaricus bisporus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
commercial preparation
-
Agaricus bisporus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
3900
-
mushroom tyrosinase solution (200 U/ml) added in the mushroom tyrosinase inhibition assay Agaricus bisporus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-tyrosine + O2 + AH2
-
Agaricus bisporus L-dopa + H2O + A
-
?

Synonyms

Synonyms Comment Organism
polyphenol oxidase
-
Agaricus bisporus
tyrosinase
-
Agaricus bisporus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
6.8
-
mushroom tyrosinase inhibition assay at Agaricus bisporus

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
additional information
-
IC50-values above 1 mM for artocarpin, cycloartocarpin, and cycloartocarpesin Agaricus bisporus additional information
0.0005254
-
-
Agaricus bisporus artocarpesin
0.0005733
-
-
Agaricus bisporus steppogenin
0.0006628
-
-
Agaricus bisporus isoartocarpesin
0.001545
-
-
Agaricus bisporus artocarpanone
0.01035
-
-
Agaricus bisporus dihydromorin
0.04793
-
-
Agaricus bisporus artocarpfuranol
0.06028
-
-
Agaricus bisporus brosimone I
0.06873
-
-
Agaricus bisporus cyanomaclurin
0.0716
-
-
Agaricus bisporus kojic acid
0.09438
-
-
Agaricus bisporus carpachromene
0.1666
-
-
Agaricus bisporus cudraflavone B
0.2009
-
-
Agaricus bisporus artocarpetin
0.4647
-
-
Agaricus bisporus norartocarpetin