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Literature summary for 1.14.18.1 extracted from

  • Criton, M.; Le Mellay-Hamon, V.
    Analogues of N-hydroxy-N-phenylthiourea and N-hydroxy-N-phenylurea as inhibitors of tyrosinase and melanin formation (2008), Bioorg. Med. Chem. Lett., 18, 3607-3610.
    View publication on PubMed
Search for more literature for 1.14.18.1

Application

Application Comment Organism
drug development inhibitor 1-hydroxy-3-phenylurea is a promising candidate for preclinical drug development for skin hyperpigmentation application Agaricus bisporus

Inhibitors

Inhibitors Comment Organism Structure
1-(2,4-dimethoxyphenyl)-3-hydroxyurea
-
 Agaricus bisporus
1-(4-bromophenyl)-3-hydroxyurea
-
 Agaricus bisporus
1-(4-butoxyphenyl)-3-hydroxyurea
-
 Agaricus bisporus
1-hydroxy-1,3-dimethyl-3-phenylurea
-
 Agaricus bisporus
1-hydroxy-1-methyl-3-(4-nitrophenyl)urea
-
 Agaricus bisporus
1-hydroxy-1-methyl-3-phenylurea
-
 Agaricus bisporus
1-hydroxy-3-(4-hydroxyphenyl)urea
-
 Agaricus bisporus
1-hydroxy-3-(4-methoxyphenyl)urea
-
 Agaricus bisporus
1-hydroxy-3-(4-nitrophenyl)urea
-
 Agaricus bisporus
1-hydroxy-3-phenylthiourea
-
 Agaricus bisporus
1-hydroxy-3-phenylurea also retains a substantial potency in cell culture by reducing pigment synthesis by 78% Agaricus bisporus
1-hydroxy-3-[4-(trifluoromethyl)phenyl]urea
-
 Agaricus bisporus
1-methoxy-3-(4-nitrophenyl)thiourea
-
 Agaricus bisporus
1-methoxy-3-naphthalen-2-ylthiourea
-
 Agaricus bisporus
1-methoxy-3-phenylurea
-
 Agaricus bisporus
1-[4-(benzyloxy)phenyl]-3-hydroxyurea
-
 Agaricus bisporus
1-[[tert-butyl(dimethyl)silyl]oxy]-3-phenylurea
-
 Agaricus bisporus
3-(4-bromophenyl)-1-hydroxy-1-methylurea
-
 Agaricus bisporus
3-hydroxy-1-methyl-1-phenylurea
-
 Agaricus bisporus
3-methoxy-1-methyl-1-phenylurea
-
 Agaricus bisporus
hydroquinone
-
 Agaricus bisporus
kojic acid
-
 Agaricus bisporus
additional information NHOH moiety is important for tyrosinase inhibition Agaricus bisporus
N',N'''-benzene-1,4-diylbis(1-hydroxyurea)
-
 Agaricus bisporus
N-hydroxy-N-(phenylcarbamoyl)acetamide
-
 Agaricus bisporus
N-phenylthiourea PTU induces a strong inhibition of the tyrosinase activity Agaricus bisporus
N-phenylurea
-
 Agaricus bisporus

Organism

Organism UniProt Comment Textmining
Agaricus bisporus
-
-
-

Synonyms

Synonyms Comment Organism
tyrosinase
-
 Agaricus bisporus

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
additional information
-
 IC50 values for N-phenylurea, 1-(2,4-dimethoxyphenyl)-3-hydroxyurea, 1-(4-butoxyphenyl)-3-hydroxyurea, 3-(4-bromophenyl)-1-hydroxy-1-methylurea, 1-methoxy-3-phenylurea, 1-hydroxy-1-methyl-3-phenylurea, 1-hydroxy-1,3-dimethyl-3-phenylurea, 3-methoxy-1-methyl-1-phenylurea, 1-hydroxy-3-phenylthiourea, 1-methoxy-3-(4-nitrophenyl)thiourea are above 1 mM Agaricus bisporus additional information
0.00029
-
-
 Agaricus bisporus 1-hydroxy-3-phenylurea
0.0018
-
-
 Agaricus bisporus N-phenylthiourea
0.0026
-
-
 Agaricus bisporus 1-hydroxy-3-(4-nitrophenyl)urea
0.0027
-
-
 Agaricus bisporus 1-(4-bromophenyl)-3-hydroxyurea
0.0043
-
-
 Agaricus bisporus 1-hydroxy-3-[4-(trifluoromethyl)phenyl]urea
0.0063
-
-
 Agaricus bisporus 1-[4-(benzyloxy)phenyl]-3-hydroxyurea
0.016
-
-
 Agaricus bisporus 3-hydroxy-1-methyl-1-phenylurea
0.026
-
-
 Agaricus bisporus 1-methoxy-3-naphthalen-2-ylthiourea
0.027
-
-
 Agaricus bisporus N',N'''-benzene-1,4-diylbis(1-hydroxyurea)
0.032
-
-
 Agaricus bisporus 1-hydroxy-3-(4-methoxyphenyl)urea
0.037
-
-
 Agaricus bisporus hydroquinone
0.041
-
-
 Agaricus bisporus 1-hydroxy-3-(4-hydroxyphenyl)urea
0.07
-
-
 Agaricus bisporus 1-[[tert-butyl(dimethyl)silyl]oxy]-3-phenylurea
0.075
-
-
 Agaricus bisporus kojic acid
0.17
-
-
 Agaricus bisporus N-hydroxy-N-(phenylcarbamoyl)acetamide
0.77
-
-
 Agaricus bisporus 1-hydroxy-1-methyl-3-(4-nitrophenyl)urea