Activating Compound | Comment | Organism | Structure |
---|---|---|---|
additional information | UVA induced oxidative stress is considered to promote melanogenesis and serious skin damage. UVA-induced reactive oxygen species (ROS), ROS causes tyrosinase gene transcription | Homo sapiens |
Application | Comment | Organism |
---|---|---|
pharmacology | results indicate that the polyvinylpyrrolidone (PVP)-wrapped fullerene derivative (Radical Sponge) could be expected for its wide-ranged application as a whitening cosmetic material | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
arbutin | as compared with two major effective cosmetic additives, arbutin and L-ascorbic acid, the polyvinylpyrrolidone (PVP)-wrapped fullerene derivative (Radical Sponge) shows the more marked depigmenting effect in human melanocytes or melanoma cells | Homo sapiens | |
L-ascorbic acid | as compared with two major effective cosmetic additives, arbutin and L-ascorbic acid, the polyvinylpyrrolidone (PVP)-wrapped fullerene derivative (Radical Sponge) shows the more marked depigmenting effect in human melanocytes or melanoma cells | Homo sapiens | |
polyvinylpyrrolidone (PVP)-wrapped fullerene derivative | inhibitory effect of the water-soluble polymer-wrapped derivative of fullerene, named Radical Sponge. As compared with two major effective cosmetic additives, arbutin and L-ascorbic acid, the polyvinylpyrrolidone (PVP)-wrapped fullerene derivative (Radical Sponge) shows the more marked depigmenting effect in human melanocytes or melanoma cells | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
HMV-II cell | human melanoma cell | Homo sapiens | - |
NHEM cell | human normal epidermis melanocytes | Homo sapiens | - |
skin | human fresh skin tissues from volunteers | Homo sapiens | - |
Synonyms | Comment | Organism |
---|---|---|
tyrosinase | - |
Homo sapiens |