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Literature summary for 1.14.18.1 extracted from

  • Espin, J.C.; Varon, R.; Fenoll, L.G.; Gilabert, M.A.; Garcia-Ruiz, P.A.; Tudela, J.; Garcia-Canovas, F.
    Kinetic characterization of the substrate specificity and mechanism of mushroom tyrosinase (2000), Eur. J. Biochem., 267, 1270-1279.
    View publication on PubMed

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.08
-
4-hydroxyanisole
-
Agaricus bisporus
0.17
-
4-ethoxyphenol
-
Agaricus bisporus
0.21
-
L-tyrosine
-
Agaricus bisporus
0.3
-
catechol
-
Agaricus bisporus
0.44
-
4-hydroxyphenyl propionic acid
-
Agaricus bisporus
0.51
-
tyramine
-
Agaricus bisporus
0.7
-
phenol
-
Agaricus bisporus
0.8
-
L-Dopa
-
Agaricus bisporus
1
-
dopa methyl ester
-
Agaricus bisporus
1.2
-
L-alpha-methyl tyrosine
-
Agaricus bisporus
1.89
-
3,4-dihydroxyphenyl propionic acid
-
Agaricus bisporus
1.91
-
4-hydroxyphenyl acetic acid
-
Agaricus bisporus
2.2
-
dopamine
-
Agaricus bisporus
2.36
-
4-methylcatechol
-
Agaricus bisporus
2.8
-
4-tert-butylcatechol
-
Agaricus bisporus
5.1
-
3,4-dihydroxyphenyl propionic acid
-
Agaricus bisporus
6.8
-
L-alpha-methyldopa
-
Agaricus bisporus
7.1
-
L-isoproterenol
-
Agaricus bisporus

Organism

Organism UniProt Comment Textmining
Agaricus bisporus
-
-
-

Reaction

Reaction Comment Organism Reaction ID
L-tyrosine + O2 = dopaquinone + H2O proposed structural reaction mechanism for the monophenolase and diphenolase activity Agaricus bisporus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2 catechol + O2
-
Agaricus bisporus 2 1,2-benzoquinone + 2 H2O
-
r
2 L-dopa + O2
-
Agaricus bisporus 2 dopaquinone + 2 H2O
-
r
3,4-dihydroxyphenyl propionic acid + O2
-
Agaricus bisporus 2-(3,4-dioxocyclohexa-1,5-dien-1-yl)propionic acid + H2O
-
r
4-ethoxyphenol + O2
-
Agaricus bisporus ?
-
?
4-hydroxyanisole + O2
-
Agaricus bisporus 3,4-dihydoxyanisol + H2O
-
r
4-hydroxyphenyl acetic acid + O2
-
Agaricus bisporus ?
-
?
4-hydroxyphenyl propionic acid + O2
-
Agaricus bisporus 3,4-dihydroxyphenyl propionic acid + H2O
-
r
4-methylcatechol + O2
-
Agaricus bisporus 4-methyl-o-benzoquinone + H2O
-
?
4-tert-butylcatechol + O2
-
Agaricus bisporus 4-tert-butyl-o-benzoquinone + H2O
-
r
dopa methyl ester + O2
-
Agaricus bisporus dopaquinone methyl ester + H2O
-
r
dopamine + O2
-
Agaricus bisporus dopamine quinone + H2O
-
r
L-alpha-methyl tyrosine + O2
-
Agaricus bisporus L-alpha-methyldopa + H2O
-
r
L-alpha-methyldopa + H2O
-
Agaricus bisporus L-alpha-methyl tyrosine + O2
-
r
L-alpha-methyldopa + O2
-
Agaricus bisporus L-alpha-methyldopaquinone + H2O
-
r
L-DOPA + O2
-
Agaricus bisporus dopaquinone + H2O
-
r
L-isoproterenol + O2
-
Agaricus bisporus 1-[1-hydroxy-2-(propan-2-ylamino)ethyl]-3,4-dioxocyclohexa-1,5-diene + H2O
-
r
L-tyrosine + O2
-
Agaricus bisporus dopaquinone + H2O
-
r
L-tyrosine + O2
-
Agaricus bisporus L-DOPA + H2O
-
r
phenol + O2
-
Agaricus bisporus ?
-
?
phenol + O2
-
Agaricus bisporus catechol + H2O
-
r
tyramine + O2
-
Agaricus bisporus dopamine + H2O
-
r

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
0.6
-
L-alpha-methyl tyrosine
-
Agaricus bisporus
7.9
-
L-tyrosine
-
Agaricus bisporus
12.7
-
phenol
-
Agaricus bisporus
25.9
-
tyramine
-
Agaricus bisporus
29.4
-
L-isoproterenol
-
Agaricus bisporus
35.5
-
dopa methyl ester
-
Agaricus bisporus
44.3
-
4-hydroxyphenyl acetic acid
-
Agaricus bisporus
44.3
-
L-alpha-methyldopa
-
Agaricus bisporus
66.7
-
4-hydroxyphenyl propionic acid
-
Agaricus bisporus
107
-
L-Dopa
-
Agaricus bisporus
132
-
4-ethoxyphenol
-
Agaricus bisporus
184
-
4-hydroxyanisole
-
Agaricus bisporus
439
-
dopamine
-
Agaricus bisporus
554
-
3,4-dihydroxyphenyl propionic acid
-
Agaricus bisporus
632
-
3,4-dihydroxyphenyl propionic acid
-
Agaricus bisporus
642
-
4-tert-butylcatechol
-
Agaricus bisporus
842
-
4-methylcatechol
-
Agaricus bisporus
878
-
catechol
-
Agaricus bisporus