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Literature summary for 1.14.17.3 extracted from

  • Scopsi, L.; Lee, R.; Gullo, M.; Collini, P.; Husten, E.J.; Eipper, B.A.
    Peptidylglycine alpha-amidating monooxygenase in neuroendocrine tumors: its identification, characterization, quantification, and relation to the grade of morphologic differentiation, amidated peptide content, and granin immunocytochemistry (1998), Appl. Immunohistochem., 6, 120-132.
No PubMed abstract available
Search for more literature for 1.14.17.3

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane
-
 Homo sapiens 16020
-
secretory granule chromaffin granules Homo sapiens 30141
-

Metals/Ions

Metals/Ions Comment Organism Structure
Cu2+
-
 Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
peptidylglycine + ascorbate + O2 Homo sapiens amidation of neurohormonal peptides peptidyl(2-hydroxyglycine) + dehydroascorbate + H2O
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
bronchial cancer cell
-
 Homo sapiens
-
gastric cancer cell
-
 Homo sapiens
-
gastrinoma cell
-
 Homo sapiens
-
intestinal cancer cell
-
 Homo sapiens
-
medullary thyroid carcinoma cell
-
 Homo sapiens
-
neuroendocrine tumor cell
-
 Homo sapiens
-
pancreatic cancer cell
-
 Homo sapiens
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
 peptidylglycine alpha-amidating and alpha-hydroxylating monooxygenase activities in several tumor tissue extracts, comparison with immunological analysis, overview, highest activity in medullary thyroid carcinoma Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
alpha-N-acetyl-Tyr-Val-Gly + ascorbate + O2
-
 Homo sapiens alpha-N-acetyl-Tyr-Val-2-hydroxyglycine + dehydroascorbate + H2O
-
 ?
peptidylglycine + ascorbate + O2 COOH-terminal glycine Homo sapiens peptidyl(2-hydroxyglycine) + dehydroascorbate + H2O
-
 ?
peptidylglycine + ascorbate + O2 amidation of neurohormonal peptides Homo sapiens peptidyl(2-hydroxyglycine) + dehydroascorbate + H2O
-
 ?

Cofactor

Cofactor Comment Organism Structure
ascorbate dependent on Homo sapiens