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Literature summary for 1.14.17.1 extracted from
- Simple photometric assay of dopamine-beta-hydroxylase activity in human blood: Useful in clinical chemistry (2009), Clin. Chem., 55, 193-194.
Application
| Application | Comment | Organism |
|---|---|---|
| medicine | simple photometric method in clinical chemistry for determining the DBH activity in human blood, which parallels the protein level, and the high interest in DBH activity in the blood in various diseases that affect central and peripheral catecholamine systems, such as DBH deficiency and pheochromocytoma | Homo sapiens |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| blood plasma | a functional -1021C3T polymorphism in the DBH gene regulates plasma DBH activity, and individuals with the genotype T/T have genetically determined low DBH activity in their plasma | Homo sapiens | - |
| blood serum | - |
Homo sapiens | - |
| cerebrospinal fluid | the DBH activity:DBH protein ratio is the same in human serum and cerebrospinal fluid and does not change in patients with Parkinson disease, whose cerebrospinal fluid has very low DBH activity and protein levels compared with cerebrospinal fluid from healthy individuals | Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| tyramine + ascorbate + O2 | - |
Homo sapiens | octopamine + dehydroascorbate + H2O | - |
? |  |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| DBH | - |
Homo sapiens |
| dopamine beta-hydroxylase | - |
Homo sapiens |
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Release 2023.1 (January 2023)
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