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Literature summary for 1.14.17.1 extracted from

  • Mitrochkine, A.A.; Eydoux, E.; Gil, G.; Reglier, M.
    Aminoindanes in oxygen atom transfer reactions, 1: Enzymatic hydroxylation by dopamine beta-hydroxylase (1998), Eur. J. Org. Chem., 1998, 1171-1176.
No PubMed abstract available

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
3.8
-
2-aminoindane 37°C, 0.2 M acetate buffe, pI 6, with 30 mM NEM, 1 mM K4Fe(CN)6, 5 mM CuSO4 Bos taurus

Organism

Organism UniProt Comment Textmining
Bos taurus
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-
-

Purification (Commentary)

Purification (Comment) Organism
partially, from adrenal medulla after crude extract PEG 6000 precipitation and DEAE-Sepharose chromatography Bos taurus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2-aminoindane + ascorbate + O2 Stereochemistry is in contrast to the stereochemical course of pro-R hydroxylation of the DBH/phenethylamine reaction. Studies with stereospecifically deuterium labelled substrate show that the production of (1S)-aminoindanol ir the result of sterospecific pro-S hydrogen abstraction followed by the oxygen binding with overall retention of configuration Bos taurus trans-(1S,2S)-2-amino-1-indanol + H2O
-
?

Synonyms

Synonyms Comment Organism
DBH
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Bos taurus
dopamine beta-hydroxylase
-
Bos taurus

Cofactor

Cofactor Comment Organism Structure
ascorbate
-
Bos taurus