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Literature summary for 1.14.17.1 extracted from

  • DeWolf, W.E.; Chambers, P.A.; Southan, C.; Saunders, D.; Kruse, L.I.
    Inactivation of dopamine beta-hydroxylase by beta-ethynyltyramine: kinetic characterization and covalent modification of an active site peptide (1989), Biochemistry, 28, 3833-3842.
    View publication on PubMed
Search for more literature for 1.14.17.1

Inhibitors

Inhibitors Comment Organism Structure
beta-Ethynyltyramine and enantiomers, mechanism of inhibition Bos taurus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3,4-dihydroxyphenethylamine + ascorbate + O2 Bos taurus enzyme plays a key role in the biosynthetic interconversion of neurotransmitters noradrenaline + dehydroascorbate + H2O
-
 ?

Organism

Organism UniProt Comment Textmining
Bos taurus
-
-
-

Reaction

Reaction Comment Organism Reaction ID
dopamine + 2 ascorbate + O2 = noradrenaline + 2 monodehydroascorbate + H2O mechanism Bos taurus
a

Source Tissue

Source Tissue Comment Organism Textmining
adrenal medulla
-
 Bos taurus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3,4-dihydroxyphenethylamine + ascorbate + O2
-
 Bos taurus noradrenaline + dehydroascorbate + H2O norepinephrine ?
3,4-dihydroxyphenethylamine + ascorbate + O2 enzyme plays a key role in the biosynthetic interconversion of neurotransmitters Bos taurus noradrenaline + dehydroascorbate + H2O
-
 ?

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.015
-
 beta-ethynytyramine R,S-1 Bos taurus
0.057
-
 beta-ethynytyramine S-1, in the presence of ascorbate Bos taurus
0.208
-
 beta-ethynytyramine S-1 Bos taurus