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Literature summary for 1.14.16.4 extracted from

  • Tidemand, K.; Christensen, H.; Hoeck, N.; Harris, P.; Boesen, J.; Peters, G.
    Stabilization of tryptophan hydroxylase 2 by L-phenylalanine-induced dimerization (2016), FEBS Open Bio, 6, 987-999 .
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Escherichia coli BL21(DE3) cells Homo sapiens

General Stability

General Stability Organism
in the presence of L-Phe, the enzyme dimer displays significantly increased half-life Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
L-tryptophan + tetrahydrobiopterin + O2 Homo sapiens
-
5-hydroxy-L-tryptophan + 4a-hydroxytetrahydrobiopterin
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Purification (Commentary)

Purification (Comment) Organism
dextrin Sepharose column chromatography and Superdex 200 gel filtration Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-tryptophan + tetrahydrobiopterin + O2
-
Homo sapiens 5-hydroxy-L-tryptophan + 4a-hydroxytetrahydrobiopterin
-
?

Subunits

Subunits Comment Organism
homodimer
-
Homo sapiens

Synonyms

Synonyms Comment Organism
TPH2
-
Homo sapiens
tryptophan hydroxylase 2
-
Homo sapiens

Temperature Stability [°C]

Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
40
-
melting temperature Homo sapiens