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Literature summary for 1.14.16.4 extracted from

  • Matthes, S.; Mosienko, V.; Bashammakh, S.; Alenina, N.; Bader, M.
    Tryptophan hydroxylase as novel target for the treatment of depressive disorders (2010), Pharmacology, 85, 95-109.
    View publication on PubMed

Protein Variants

Protein Variants Comment Organism
R441H naturally occuring missense mutation Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
4-chloro-L-phenylalanine irreversible inhibitor Homo sapiens
4-chloro-L-phenylalanine irreversible inhibitor Mus musculus

Metals/Ions

Metals/Ions Comment Organism Structure
Fe2+
-
Mus musculus
Fe2+
-
Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-tryptophan + tetrahydrobiopterin
-
Mus musculus 5-hydroxy-L-tryptophan + 4a-hydroxytetrahydrobiopterin
-
?
L-tryptophan + tetrahydrobiopterin
-
Homo sapiens 5-hydroxy-L-tryptophan + 4a-hydroxytetrahydrobiopterin
-
?

Synonyms

Synonyms Comment Organism
tryptophan hydroxylase 1
-
Mus musculus
tryptophan hydroxylase 1
-
Homo sapiens
tryptophan hydroxylase 2
-
Mus musculus
tryptophan hydroxylase 2
-
Homo sapiens

General Information

General Information Comment Organism
malfunction serveral single nucleotide polymorphisms are associated with depression, suicidal behavior and bipolar disorder Homo sapiens