Literature summary for 1.14.16.4 extracted from

Hofto, L.R.; Lee, C.E.; Cafiero, M.
The importance of aromatic-type interactions in serotonin synthesis: Protein-ligand interactionsin tryptophan hydroxylase and aromatic amino acid decarboxylase (2008), J. Comput. Chem., 30, 1111-1115.

Search for more literature for 1.14.16.4

Crystallization (Commentary)

Crystallization (Comment)	Organism
residue Phe241 forms a displaced sandwich-type pi-complex with tetrahydrobiopterin, this complex has a counterpoise-corrected second order Moller Plesset Theory interaction energy of about 24.68 kcal/mol	synthetic construct

Protein Variants

Protein Variants	Comment	Organism
F241A	drop in interaction energy of 58%	synthetic construct
F241G	loses 76% of the interaction energy	synthetic construct
F241I	drop in interaction energy of 4%, reduction in interaction for the isoleucine mutation may cause a reduction in the production of 5-hydroxy-L-tryptophan, and in turn, a reduction in serotonin. This may lead to onset of symptoms, such as anxiety, depression, and OCD	synthetic construct
F241L	retains the interaction energy necessary to keep protein function	synthetic construct
F241Q	retains the interaction energy necessary to keep protein function	synthetic construct
F241Y	retains the interaction energy necessary to keep protein function	synthetic construct

Organism

Organism	UniProt	Comment	Textmining
synthetic construct	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
L-tryptophan + tetrahydrobiopterin + O2	-	synthetic construct	5-hydroxy-L-tryptophan + 4a-hydroxytetrahydrobiopterin	-	?

Synonyms

Synonyms	Comment	Organism
TRpOH	-	synthetic construct
tryptophan hydroxylase	-	synthetic construct

Cofactor

Cofactor	Comment	Organism	Structure
tetrahydrobiopterin	-	synthetic construct

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Release 2023.1 (January 2023)