Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-tryptophan + tetrahydrobiopterin + O2 | Rattus norvegicus | the enzyme is involved in emotional responses | 5-hydroxy-L-tryptophan + 4a-hydroxytetrahydrobiopterin | - |
? | |
additional information | Rattus norvegicus | chronic treatment with milnacipran or fluvoxamine is effective to improve both the hyperemotional behavior and the loss of TPH-positive cells in olfactory bulbectomized rats, overview | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
male Wistar rats | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | dorsal and median raphe | Rattus norvegicus | - |
additional information | olfactory bulbectomized rats, i.e. OBX rats, with olfactory bulbs removed by suction, no significant difference in the effects on TPH immunoreactivity in the median raphe of OBX rats between vehicle- and antidepressants-treated animals | Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-tryptophan + tetrahydrobiopterin + O2 | - |
Rattus norvegicus | 5-hydroxy-L-tryptophan + 4a-hydroxytetrahydrobiopterin | - |
? | |
L-tryptophan + tetrahydrobiopterin + O2 | the enzyme is involved in emotional responses | Rattus norvegicus | 5-hydroxy-L-tryptophan + 4a-hydroxytetrahydrobiopterin | - |
? | |
additional information | chronic treatment with milnacipran or fluvoxamine is effective to improve both the hyperemotional behavior and the loss of TPH-positive cells in olfactory bulbectomized rats, overview | Rattus norvegicus | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
TPH | - |
Rattus norvegicus |
tryptophan hydroxylase | - |
Rattus norvegicus |