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Literature summary for 1.14.16.4 extracted from

  • Ham, B.; Lee, B.; Paik, J.; Kang, R.; Choi, M.; Choi, I.; Lee, M.
    Association between the tryptophan hydroxylase-1 gene A218C polymorphism and citalopram antidepressant response in a Korean population (2007), Prog. Neuropsychopharmacol. Biol. Psychiatry, 31, 104-107.
    View publication on PubMed
Search for more literature for 1.14.16.4

Cloned(Commentary)

Cloned (Comment) Organism
TPH1, genotyping in Korean population with major depressive disorder patients, overview Homo sapiens

Protein Variants

Protein Variants Comment Organism
additional information A218C is a naturally occuring polymorphism in TPH1, genotyping in Korean population with major depressive disorder patients, remission rate to citalopram treatment was worse in MDD subjects with the TPH1 A/A and A/C genotypes than in those with the TPH1 C/C genotype, overview Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
citalopram selective serotonin reuptake inhibitors, like citalopram, exert their activity enhancing the general serotonergic tone, citalopram is the most selective one with little or no affinity for a variety of receptor types, association between gene TPH1 A218C polymorphism and citalopram antidepressant response in a Korean population, overview Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
L-tryptophan + tetrahydrobiopterin + O2 Homo sapiens TPH1 is the rate-limiting enzyme in serotonin biosynthesis 5-hydroxy-L-tryptophan + 4a-hydroxytetrahydrobiopterin
-
 ?
additional information Homo sapiens association between the tryptophan hydroxylase-1 gene A218C polymorphism and citalopram antidepressant response in a Korean population with major depressive disorder ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens P17752 Korean subjects with major depressive disorder
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-tryptophan + tetrahydrobiopterin + O2
-
 Homo sapiens 5-hydroxy-L-tryptophan + 4a-hydroxytetrahydrobiopterin
-
 ?
L-tryptophan + tetrahydrobiopterin + O2 TPH1 is the rate-limiting enzyme in serotonin biosynthesis Homo sapiens 5-hydroxy-L-tryptophan + 4a-hydroxytetrahydrobiopterin
-
 ?
additional information association between the tryptophan hydroxylase-1 gene A218C polymorphism and citalopram antidepressant response in a Korean population with major depressive disorder Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
TPH1
-
 Homo sapiens
tryptophan hydroxylase-1
-
 Homo sapiens