Literature summary for 1.14.16.4 extracted from

Nishimura, K.; Kitamura, Y.; Inoue, T.; Umesono, Y.; Yoshimoto, K.; Takeuchi, K.; Taniguchi, T.; Agata, K.
Identification and distribution of tryptophan hydroxylase (TPH)-positive neurons in the planarian Dugesia japonica (2007), Neurosci. Res., 59, 101-106.

Search for more literature for 1.14.16.4

Application

Application	Comment	Organism
analysis	a Dugesia japonica TPH antibody is a useful marker for serotonergic neurons in planarians	Dugesia japonica

Cloned(Commentary)

Cloned (Comment)	Organism
gene TPH, DNA and amino acid sequence determination and analysis	Dugesia japonica

Protein Variants

Protein Variants	Comment	Organism
additional information	TPH knockout, by RNAi, animals shows reduced serotonin levels compared to wild-type animals	Dugesia japonica

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
L-tryptophan + tetrahydrobiopterin + O2	Dugesia japonica	the enzyme is required for serotonin, i.e. 5-hydroxytryptamine, biosynthesis	5-hydroxy-L-tryptophan + 4a-hydroxytetrahydrobiopterin	-	?

Organism

Organism	UniProt	Comment	Textmining
Dugesia japonica	A7VKD9	a planarian, gene TPH	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
additional information	expression pattern of TPH in whole animals, in situ hybridization, overview	Dugesia japonica	-
nervous system	main expression of gene TPH at commissure axonal connections in the ventral nerve cords	Dugesia japonica	-
neuron	serotonergic	Dugesia japonica	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
L-tryptophan + tetrahydrobiopterin + O2	-	Dugesia japonica	5-hydroxy-L-tryptophan + 4a-hydroxytetrahydrobiopterin	-	?
L-tryptophan + tetrahydrobiopterin + O2	the enzyme is required for serotonin, i.e. 5-hydroxytryptamine, biosynthesis	Dugesia japonica	5-hydroxy-L-tryptophan + 4a-hydroxytetrahydrobiopterin	-	?

Subunits

Subunits	Comment	Organism
tetramer	a conserved leucine zipper in the C-terminal domain is required for the tetramerization of TPH, overview	Dugesia japonica

Synonyms

Synonyms	Comment	Organism
TPH	-	Dugesia japonica
tryptophan hydroxylase	-	Dugesia japonica

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Release 2023.1 (January 2023)