Cloned (Comment) | Organism |
---|---|
expression analysis of wild-type and mutant enzymes in brain samples | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
additional information | genotyping of naturally occuring single nucleotide polymorphisms of TPH2 in brain tissues, identification of 27 mutations, the mutations causing allelicexpression imbalance are associated with depressiona nd suicide, overview | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-tryptophan + tetrahydrobiopterin + O2 | Homo sapiens | - |
5-hydroxy-L-tryptophan + 4a-hydroxytetrahydrobiopterin | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q8IWU9 | isozyme TPH2 | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | expression of TPH2 | Homo sapiens | - |
neuron | serotonergic, expression of TPH2 | Homo sapiens | - |
pons | expression of TPH2 | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-tryptophan + tetrahydrobiopterin + O2 | - |
Homo sapiens | 5-hydroxy-L-tryptophan + 4a-hydroxytetrahydrobiopterin | - |
? |
Synonyms | Comment | Organism |
---|---|---|
TPH2 | - |
Homo sapiens |
tryptophan hydroxylase 2 | - |
Homo sapiens |