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Literature summary for 1.14.16.4 extracted from

  • Lim, J.E.; Pinsonneault, J.; Sadee, W.; Saffen, D.
    Tryptophan hydroxylase 2 (TPH2) haplotypes predict levels of TPH2 mRNA expression in human pons (2007), Mol. Psychiatry, 12, 491-501.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
expression analysis of wild-type and mutant enzymes in brain samples Homo sapiens

Protein Variants

Protein Variants Comment Organism
additional information genotyping of naturally occuring single nucleotide polymorphisms of TPH2 in brain tissues, identification of 27 mutations, the mutations causing allelicexpression imbalance are associated with depressiona nd suicide, overview Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
L-tryptophan + tetrahydrobiopterin + O2 Homo sapiens
-
5-hydroxy-L-tryptophan + 4a-hydroxytetrahydrobiopterin
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens Q8IWU9 isozyme TPH2
-

Source Tissue

Source Tissue Comment Organism Textmining
brain expression of TPH2 Homo sapiens
-
neuron serotonergic, expression of TPH2 Homo sapiens
-
pons expression of TPH2 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-tryptophan + tetrahydrobiopterin + O2
-
Homo sapiens 5-hydroxy-L-tryptophan + 4a-hydroxytetrahydrobiopterin
-
?

Synonyms

Synonyms Comment Organism
TPH2
-
Homo sapiens
tryptophan hydroxylase 2
-
Homo sapiens