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Literature summary for 1.14.16.4 extracted from

  • Malek, Z.S.; Sage, D.; Pevet, P.; Raison, S.
    Daily rhythm of tryptophan hydroxylase-2 messenger ribonucleic acid within raphe neurons is induced by corticoid daily surge and modulated by enhanced locomotor activity (2007), Endocrinology, 148, 5165-5172.
    View publication on PubMed
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
L-tryptophan + tetrahydrobiopterin + O2 Rattus norvegicus TPH is rate-limiting in serotonin biosynthesis 5-hydroxy-L-tryptophan + 4a-hydroxytetrahydrobiopterin
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 ?
additional information Rattus norvegicus the enzyme expression in brain is correlated to glucocorticoid fluctuations, e.g. corticosterone, overview ?
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 ?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus Q8CGU9 gene TPH2
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Source Tissue

Source Tissue Comment Organism Textmining
brain circadian expression of TPH in dorsal and median raphe in correlation to glucocorticoid fluctuations, e.g. corticosterone, expression pattern, overview Rattus norvegicus
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-tryptophan + tetrahydrobiopterin + O2
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 Rattus norvegicus 5-hydroxy-L-tryptophan + 4a-hydroxytetrahydrobiopterin
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 ?
L-tryptophan + tetrahydrobiopterin + O2 TPH is rate-limiting in serotonin biosynthesis Rattus norvegicus 5-hydroxy-L-tryptophan + 4a-hydroxytetrahydrobiopterin
-
 ?
additional information the enzyme expression in brain is correlated to glucocorticoid fluctuations, e.g. corticosterone, overview Rattus norvegicus ?
-
 ?

Synonyms

Synonyms Comment Organism
TPH2
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 Rattus norvegicus
tryptophan hydroxylase-2
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 Rattus norvegicus