Cloned (Comment) | Organism |
---|---|
gene tph, DNA and amino acid sequence deterination and analysis, expression analysis, phylogenetic analysis | Ciona intestinalis |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-tryptophan + tetrahydrobiopterin + O2 | Ciona intestinalis | rate-limiting enzyme in serotonin synthesis | 5-hydroxy-L-tryptophan + 4a-hydroxytetrahydrobiopterin | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Ciona intestinalis | A1Y9J6 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
larva | TPH expression pattern during development, TPH expression was found from tailbud stage in the precursor cells of the visceral ganglion and in the tail | Ciona intestinalis | - |
neuron | TPHexpressing neurons form two clusters in the anterior central nervous system at the level of the visceral ganglion | Ciona intestinalis | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-tryptophan + tetrahydrobiopterin + O2 | - |
Ciona intestinalis | 5-hydroxy-L-tryptophan + 4a-hydroxytetrahydrobiopterin | - |
? | |
L-tryptophan + tetrahydrobiopterin + O2 | rate-limiting enzyme in serotonin synthesis | Ciona intestinalis | 5-hydroxy-L-tryptophan + 4a-hydroxytetrahydrobiopterin | - |
? |
Synonyms | Comment | Organism |
---|---|---|
TPH | - |
Ciona intestinalis |
tryptophan hydroxylase | - |
Ciona intestinalis |