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Literature summary for 1.14.16.4 extracted from

  • Lopez de Lara, C.; Brezo, J.; Rouleau, G.; Lesage, A.; Dumont, M.; Alda, M.; Benkelfat, C.; Turecki, G.
    Effect of tryptophan hydroxylase-2 gene variants on suicide risk in major depression (2007), Biol. Psychiatry, 62, 72-80.
    View publication on PubMed
Search for more literature for 1.14.16.4

Cloned(Commentary)

Cloned (Comment) Organism
TPH2, DNA and amino acid sequence determination and analysis, genotyping Homo sapiens

Protein Variants

Protein Variants Comment Organism
additional information genotyping of TPH2 in depressive patients, the single nucleotide polymorphisms rs4448731 and rs4641527 significantly predict suicide, along with cluster B personality disorders and family history of suicide, overview Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
L-tryptophan + tetrahydrobiopterin + O2 Homo sapiens
-
 5-hydroxy-L-tryptophan + 4a-hydroxytetrahydrobiopterin
-
 ?
additional information Homo sapiens TPH2 gene and its 5' upstream region variants may be involved in the predisposition to suicide in major depression disorder, however, may not play a role in impulsive-aggressive behaviors as mediators, overview ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens Q8IWU9
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-tryptophan + tetrahydrobiopterin + O2
-
 Homo sapiens 5-hydroxy-L-tryptophan + 4a-hydroxytetrahydrobiopterin
-
 ?
additional information TPH2 gene and its 5' upstream region variants may be involved in the predisposition to suicide in major depression disorder, however, may not play a role in impulsive-aggressive behaviors as mediators, overview Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
TPH2
-
 Homo sapiens
tryptophan hydroxylase-2
-
 Homo sapiens