Cloned (Comment) | Organism |
---|---|
gene TPH1, DNA and amino acid sequence determination and analysis, genotyping in Han Chinese subjects | Homo sapiens |
gene TPH2, DNA and amino acid sequence determination and analysis, genotyping in Han Chinese subjects | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
additional information | screening for TPH2 polymorphisms in Han Chinese subjects, genotyping, haplotype frequency and association analysis, naturally occuring polymorphisms of TPH2 are A90G in the 5'-UTR of exon 1, C2755A in exon 2, C10662T in intron 4, G26270A in intron 5, G33775A in intron 6, G40237A in exon 7, A83610T in exon 9, and G93329A in the 3'-UTR of exon 11, overview | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-tryptophan + tetrahydrobiopterin + O2 | Homo sapiens | - |
5-hydroxy-L-tryptophan + 4a-hydroxytetrahydrobiopterin | - |
? | |
L-tryptophan + tetrahydrobiopterin + O2 | Homo sapiens | TPH2 is the first and rate-limiting enzyme in the serotonin biosynthetic pathway | 5-hydroxy-L-tryptophan + 4a-hydroxytetrahydrobiopterin | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P17752 | Han Chinese subjects, gene TPH1 encodes isozyme TPH1 | - |
Homo sapiens | Q8IWU9 | Han Chinese subjects, gene TPH2 encoding isozyme TPH2 | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain stem | raphe nuclei | Homo sapiens | - |
IMR-32 cell | - |
Homo sapiens | - |
SH-SY5Y cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-tryptophan + tetrahydrobiopterin + O2 | - |
Homo sapiens | 5-hydroxy-L-tryptophan + 4a-hydroxytetrahydrobiopterin | - |
? | |
L-tryptophan + tetrahydrobiopterin + O2 | TPH2 is the first and rate-limiting enzyme in the serotonin biosynthetic pathway | Homo sapiens | 5-hydroxy-L-tryptophan + 4a-hydroxytetrahydrobiopterin | - |
? |
Synonyms | Comment | Organism |
---|---|---|
TPH1 | - |
Homo sapiens |
TPH2 | - |
Homo sapiens |
tryptophan hydroxylase 1 | - |
Homo sapiens |
tryptophan hydroxylase 2 | - |
Homo sapiens |