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Literature summary for 1.14.16.4 extracted from

  • Khan, I.A.; Thomas, P.
    Aroclor 1254 inhibits tryptophan hydroxylase activity in rat brain (2004), Arch. Toxicol., 78, 316-320.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
Aroclor 1254
-
Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
L-tryptophan + tetrahydropteridine + O2 Rattus norvegicus rate-limiting enzyme in synthesis of 5-hydroxy-L-tryptophan 5-hydroxy-L-tryptophan + dihydropteridine + H2O
-
?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-tryptophan + tetrahydropteridine + O2 rate-limiting enzyme in synthesis of 5-hydroxy-L-tryptophan Rattus norvegicus 5-hydroxy-L-tryptophan + dihydropteridine + H2O
-
?

Synonyms

Synonyms Comment Organism
TPH
-
Rattus norvegicus