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Literature summary for 1.14.16.2 extracted from

  • Baumann, A.; Jorge-Finnigan, A.; Jung-Kc, K.; Sauter, A.; Horvath, I.; Morozova-Roche, L.A.; Martinez, A.
    Tyrosine hydroxylase binding to phospholipid membranes prompts its amyloid aggregation and compromises bilayer integrity (2016), Sci. Rep., 6, 39488 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 1.14.16.2

Cloned(Commentary)

Cloned (Comment) Organism
expressed in BEscherichia coli BL21-CodonPlus cells Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
 Homo sapiens 5829
-
microsome
-
 Homo sapiens
-
-
mitochondrion
-
 Homo sapiens 5739
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
L-tyrosine + tetrahydrobiopterin + O2 Homo sapiens
-
 L-dopa + 4a-hydroxytetrahydrobiopterin + H2O
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Purification (Commentary)

Purification (Comment) Organism
Talon column chromatography Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-tyrosine + tetrahydrobiopterin + O2
-
 Homo sapiens L-dopa + 4a-hydroxytetrahydrobiopterin + H2O
-
 ?

Synonyms

Synonyms Comment Organism
TH1
-
 Homo sapiens
tyrosine hydroxylase
-
 Homo sapiens

General Information

General Information Comment Organism
physiological function The enzyme shows a disruptive effect on cell membranes. Incubation of isolated mitochondria with the enzyme leads to a decrease in the mitochondrial membrane potential Homo sapiens