Literature summary for 1.14.16.2 extracted from

Nagatsu, T.; Nagatsu, I.
Tyrosine hydroxylase (TH), its cofactor tetrahydrobiopterin (BH4), other catecholamine-related enzymes, and their human genes in relation to the drug and gene therapies of Parkinsons disease (PD) historical overview and future prospects (2016), J. Neural Transm., 123, 1255-1278 .

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Inhibitors

Inhibitors	Comment	Organism	Structure
L-alpha-methyl-p-tyrosine	specific and potent inhibitor	Homo sapiens

Metals/Ions

Metals/Ions	Comment	Organism	Structure
Fe2+	contains Fe2+	Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
L-tyrosine + tetrahydrobiopterin + O2	Homo sapiens	-	L-dopa + 4a-hydroxytetrahydrobiopterin + H2O	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	P07101	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
brain	-	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
L-tyrosine + tetrahydrobiopterin + O2	-	Homo sapiens	L-dopa + 4a-hydroxytetrahydrobiopterin + H2O	-	?

Subunits

Subunits	Comment	Organism
homotetramer	4 * 55533, isoform TH1, calculated from amino acid sequence	Homo sapiens
homotetramer	4 * 55973, isoform TH2, calculated from amino acid sequence	Homo sapiens
homotetramer	4 * 58080, isoform TH3, calculated from amino acid sequence	Homo sapiens
homotetramer	4 * 58521, isoform TH4, calculated from amino acid sequence	Homo sapiens

Synonyms

Synonyms	Comment	Organism
tyrosinase	-	Homo sapiens
tyrosine hydroxylase	-	Homo sapiens

Cofactor

Cofactor	Comment	Organism	Structure
tetrahydrobiopterin	-	Homo sapiens

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Release 2023.1 (January 2023)