Protein Variants | Comment | Organism |
---|---|---|
S31A | the mutant is not phosphorlyated | Homo sapiens |
S31A | the mutant is not phosphorlyated | Rattus norvegicus |
S31E | phospho-mimic mutant | Homo sapiens |
S31E | phospho-mimic mutant | Rattus norvegicus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
Golgi apparatus | - |
Homo sapiens | 5794 | - |
Golgi apparatus | - |
Rattus norvegicus | 5794 | - |
vesicle | - |
Homo sapiens | 31982 | - |
vesicle | - |
Rattus norvegicus | 31982 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-tyrosine + tetrahydrobiopterin + O2 | Homo sapiens | - |
L-dopa + 4a-hydroxytetrahydrobiopterin + H2O | - |
? | |
L-tyrosine + tetrahydrobiopterin + O2 | Rattus norvegicus | - |
L-dopa + 4a-hydroxytetrahydrobiopterin + H2O | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Rattus norvegicus | P04177 | - |
- |
Posttranslational Modification | Comment | Organism |
---|---|---|
phosphoprotein | phosphorylation at the Ser-31 site may regulate enzyme subcellular localization by enabling its transport along microtubules and is necessary for enzyme association with vesicles | Homo sapiens |
phosphoprotein | phosphorylation at the Ser-31 site may regulate enzyme subcellular localization by enabling its transport along microtubules and is necessary for enzyme association with vesicles | Rattus norvegicus |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
dopaminergic neuron | - |
Homo sapiens | - |
dopaminergic neuron | - |
Rattus norvegicus | - |
HEK-293 cell | - |
Homo sapiens | - |
PC-12 cell | - |
Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-tyrosine + tetrahydrobiopterin + O2 | - |
Homo sapiens | L-dopa + 4a-hydroxytetrahydrobiopterin + H2O | - |
? | |
L-tyrosine + tetrahydrobiopterin + O2 | - |
Rattus norvegicus | L-dopa + 4a-hydroxytetrahydrobiopterin + H2O | - |
? |
Subunits | Comment | Organism |
---|---|---|
? | x * 60000, SDS-PAGE | Homo sapiens |
? | x * 60000, SDS-PAGE | Rattus norvegicus |
Synonyms | Comment | Organism |
---|---|---|
TH1 | isoform | Homo sapiens |
TH1 | isoform | Rattus norvegicus |
tyrosine hydroxylase | - |
Homo sapiens |
tyrosine hydroxylase | - |
Rattus norvegicus |