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Literature summary for 1.14.16.2 extracted from

  • Zhang, S.; Huang, T.; Ilangovan, U.; Hinck, A.P.; Fitzpatrick, P.F.
    The solution structure of the regulatory domain of tyrosine hydroxylase (2014), J. Mol. Biol., 426, 1483-1497.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Escherichia coli BL21(DE3) cells Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
L-tyrosine + tetrahydrobiopterin + O2 Rattus norvegicus
-
3,4-dihydroxy-L-phenylalanine + dihydrobiopterin + H2O
-
?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
phosphoprotein the enzyme is phosphorylated at Ser40 by protein kinase A Rattus norvegicus

Purification (Commentary)

Purification (Comment) Organism
heparin column chromatography and Superdex 200 gel filtration Rattus norvegicus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-tyrosine + tetrahydrobiopterin + O2
-
Rattus norvegicus 3,4-dihydroxy-L-phenylalanine + dihydrobiopterin + H2O
-
?

Subunits

Subunits Comment Organism
homotetramer
-
Rattus norvegicus

Synonyms

Synonyms Comment Organism
TyrH
-
Rattus norvegicus
tyrosine hydroxylase
-
Rattus norvegicus

Cofactor

Cofactor Comment Organism Structure
tetrahydrobiopterin
-
Rattus norvegicus