Literature summary for 1.14.16.2 extracted from

Nakashima, A.; Hayashi, N.; Kaneko, Y.S.; Mori, K.; Sabban, E.L.; Nagatsu, T.; Ota, A.
Role of N-terminus of tyrosine hydroxylase in the biosynthesis of catecholamines (2009), J. Neural Transm., 116, 1355-1362.

Search for more literature for 1.14.16.2

Cloned(Commentary)

Cloned (Comment)	Organism
expressed in monkey striatum using harmless adeno-associated virus vectors and in PC-12 cells and AtT-20 cells	Homo sapiens

Protein Variants

Protein Variants	Comment	Organism
additional information	the deletion mutation of N-terminal 38-amino acids increases the binding capacity of 5,6,7,8,-tetrahydrobiopterin to tyrosine hydroxylase molecule to increase the activity and possibly to increase the stability	Homo sapiens
R37E/R38E	the point mutation increases the binding capacity of 5,6,7,8,-tetrahydrobiopterin to tyrosine hydroxylase molecule to increase the activity and possibly to increase the stability	Homo sapiens

General Stability

General Stability	Organism
the 14-3-3eta protein regulates tyrosine hydroxylase type 1 stability against degradation by acting on the N-terminus	Homo sapiens

Inhibitors

Inhibitors	Comment	Organism	Structure
adrenaline	-	Homo sapiens
dopamine	-	Homo sapiens
noradrenaline	-	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Posttranslational Modification

Posttranslational Modification	Comment	Organism
phosphoprotein	Ser31 and Ser40 are readily phosphorylated to activate tyrosine hydroxylase type 1 in vitro. Although phosphorylation of Ser19 does not directly activate tyrosine hydroxylase, chaperone 14-3-3 protein binds and activates tyrosine hydroxylase at Ser19 phosphorylated by Ca2+/calmodulin-dependent protein kinase II.	Homo sapiens

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
L-tyrosine + 5,6,7,8-tetrahydro-L-biopterin + O2	-	Homo sapiens	3,4-dihydroxy-L-phenylalanine + 4a-hydroxytetrahydro-L-biopterin	-	?

Synonyms

Synonyms	Comment	Organism
TH1	isoform	Homo sapiens
tyrosine hydroxylase	-	Homo sapiens
tyrosine hydroxylase type 1	isoform	Homo sapiens

Cofactor

Cofactor	Comment	Organism	Structure
5,6,7,8-tetrahydro-L-biopterin	-	Homo sapiens

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Release 2023.1 (January 2023)