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Literature summary for 1.14.16.2 extracted from
- Effect of alpha-synuclein on the promoter activity of tyrosine hydroxylase gene (2007), Neurosci. Bull., 23, 53-57.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| expression of gene fragment, comprising positions -495 to +25, which have regulatory promoter function, from a pGL-Basic luciferase reporter vector in MES23.5 cells and MES23.5 alpha-synuclein-overexpressing cells, alpha-synuclein is a negative regulator of the tyrosine hydroxylase expression via trans-acting function on the TH promoter, overview | Homo sapiens |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| L-tyrosine + tetrahydrobiopterin + O2 | Homo sapiens | alpha-synuclein is a negative regulator of the enzyme and the dopamine biosynthesis pathway | 3,4-dihydroxy-L-phenylalanine + 4a-hydroxytetrahydrobiopterin + H2O | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| L-tyrosine + tetrahydrobiopterin + O2 | - |
Homo sapiens | 3,4-dihydroxy-L-phenylalanine + 4a-hydroxytetrahydrobiopterin + H2O | - |
? | |
| L-tyrosine + tetrahydrobiopterin + O2 | alpha-synuclein is a negative regulator of the enzyme and the dopamine biosynthesis pathway | Homo sapiens | 3,4-dihydroxy-L-phenylalanine + 4a-hydroxytetrahydrobiopterin + H2O | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| tyrosine hydroxylase | - |
Homo sapiens |
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Release 2023.1 (January 2023)
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