Literature summary for 1.14.16.2 extracted from

Cheung, K.-J.J.Jr.; Rosales, J.L.; Lee, B.C.; Jeong, Y.G.; Lee, K.Y.
Tyrosine hydroxylase expression and Cdk5 kinase activity in ataxic cerebellum (2008), Mol. Cell. Biochem., 318, 7-12.

Search for more literature for 1.14.16.2

Activating Compound

Activating Compound	Comment	Organism	Structure
additional information	cyclin-dependent kinase 5 phosphorylates tyrosine hydroxylase, but does not induce the enzyme expression	Mus musculus

Protein Variants

Protein Variants	Comment	Organism
additional information	the pogo/pogo mouse phenotype of ataxic mice shows upregulation of tyrosine hydroxylase expression induced by enzyme phosphorylation via cyclin-dependent kinase 5, reduced Cdk5 activity in both p35-/- and p39-/- cerebellum do not correspond to defects in tyrosine hydroxylase expression, overview	Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
L-tyrosine + tetrahydrobiopterin + O2	Mus musculus	the enzyme expression is increased in ataxic mice, Cdk5 activity cannot account for abnormal tyrosine hydroxylase expression in the cerebellum	3,4-dihydroxy-L-phenylalanine + 4a-hydroxytetrahydrobiopterin + H2O	-	?

Organism

Organism	UniProt	Comment	Textmining
Mus musculus	-	-	-

Posttranslational Modification

Posttranslational Modification	Comment	Organism
phosphoprotein	cyclin-dependent kinase 5 phosphorylates tyrosine hydroxylase, but does not induce the enzyme expression	Mus musculus

Source Tissue

Source Tissue	Comment	Organism	Textmining
cerebellum	ataxic and control, high enzyme expression level in ataxic mice, dramatic difference in cerebellar tyrosine hydroxylase immunoreactivity between mutant pogo, wild-type, and mutant p35-/- and p39-/- mice, overview	Mus musculus	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
L-tyrosine + tetrahydrobiopterin + O2	-	Mus musculus	3,4-dihydroxy-L-phenylalanine + 4a-hydroxytetrahydrobiopterin + H2O	-	?
L-tyrosine + tetrahydrobiopterin + O2	the enzyme expression is increased in ataxic mice, Cdk5 activity cannot account for abnormal tyrosine hydroxylase expression in the cerebellum	Mus musculus	3,4-dihydroxy-L-phenylalanine + 4a-hydroxytetrahydrobiopterin + H2O	-	?

Synonyms

Synonyms	Comment	Organism
tyrosine hydroxylase	-	Mus musculus

Cofactor

Cofactor	Comment	Organism	Structure
tetrahydrobiopterin	-	Mus musculus

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Release 2023.1 (January 2023)