Activating Compound | Comment | Organism | Structure |
---|---|---|---|
additional information | phosphorylation at Ser40 activates the enzyme | Mus musculus |
Protein Variants | Comment | Organism |
---|---|---|
additional information | increased TH-Ser40 phosphorylation in primary mesencephalic dopaminergic neurons from PKCdelta knock-out mice, overview | Mus musculus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
additional information | dephosphorylation of Ser40, by phosphatase PP2A, inhibits the enzyme, protein kinase Cdelta increases the inhibition by activating PP2A, and physically associates with the tyrosine hydroxylase | Mus musculus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-tyrosine + tetrahydrobiopterin + O2 | Mus musculus | rate-limiting enzyme in dopamine biosynthesis, regulation by reversible phosphorylation, overview | 3,4-dihydroxy-L-phenylalanine + 4a-hydroxytetrahydrobiopterin + H2O | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
- |
- |
Posttranslational Modification | Comment | Organism |
---|---|---|
phosphoprotein | reversible phosphorylation at Ser40 regulates the enzyme activity, the phosphorylated enzyme is active, dephosphorylation is performed by phosphatase PP2A, PKCdelta physically associates with the PP2A catalytic subunit and phosphorylates the phosphatase to increase its activity, it also physically associates with tyrosine hydroxylase, inhibition of PKCdelta reduces the dephosphorylation activity of PP2A and thereby increases TH-Ser40 phosphorylation, tyrosine hydroxylase activity, and dopamine synthesis, overview | Mus musculus |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | - |
Mus musculus | - |
substantia nigra | - |
Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-tyrosine + tetrahydrobiopterin + O2 | - |
Mus musculus | 3,4-dihydroxy-L-phenylalanine + 4a-hydroxytetrahydrobiopterin + H2O | - |
? | |
L-tyrosine + tetrahydrobiopterin + O2 | rate-limiting enzyme in dopamine biosynthesis, regulation by reversible phosphorylation, overview | Mus musculus | 3,4-dihydroxy-L-phenylalanine + 4a-hydroxytetrahydrobiopterin + H2O | - |
? |
Synonyms | Comment | Organism |
---|---|---|
tyrosine hydroxylase | - |
Mus musculus |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Mus musculus |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.4 | - |
assay at | Mus musculus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
tetrahydrobiopterin | - |
Mus musculus |