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Literature summary for 1.14.16.2 extracted from

  • Zhang, D.; Kanthasamy, A.; Yang, Y.; Anantharam, V.; Kanthasamy, A.
    Protein kinase C delta negatively regulates tyrosine hydroxylase activity and dopamine synthesis by enhancing protein phosphatase-2A activity in dopaminergic neurons (2007), J. Neurosci., 27, 5349-5362.
    View publication on PubMedView publication on EuropePMC

Activating Compound

Activating Compound Comment Organism Structure
additional information phosphorylation at Ser40 activates the enzyme Mus musculus

Protein Variants

Protein Variants Comment Organism
additional information increased TH-Ser40 phosphorylation in primary mesencephalic dopaminergic neurons from PKCdelta knock-out mice, overview Mus musculus

Inhibitors

Inhibitors Comment Organism Structure
additional information dephosphorylation of Ser40, by phosphatase PP2A, inhibits the enzyme, protein kinase Cdelta increases the inhibition by activating PP2A, and physically associates with the tyrosine hydroxylase Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
L-tyrosine + tetrahydrobiopterin + O2 Mus musculus rate-limiting enzyme in dopamine biosynthesis, regulation by reversible phosphorylation, overview 3,4-dihydroxy-L-phenylalanine + 4a-hydroxytetrahydrobiopterin + H2O
-
?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
phosphoprotein reversible phosphorylation at Ser40 regulates the enzyme activity, the phosphorylated enzyme is active, dephosphorylation is performed by phosphatase PP2A, PKCdelta physically associates with the PP2A catalytic subunit and phosphorylates the phosphatase to increase its activity, it also physically associates with tyrosine hydroxylase, inhibition of PKCdelta reduces the dephosphorylation activity of PP2A and thereby increases TH-Ser40 phosphorylation, tyrosine hydroxylase activity, and dopamine synthesis, overview Mus musculus

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
Mus musculus
-
substantia nigra
-
Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-tyrosine + tetrahydrobiopterin + O2
-
Mus musculus 3,4-dihydroxy-L-phenylalanine + 4a-hydroxytetrahydrobiopterin + H2O
-
?
L-tyrosine + tetrahydrobiopterin + O2 rate-limiting enzyme in dopamine biosynthesis, regulation by reversible phosphorylation, overview Mus musculus 3,4-dihydroxy-L-phenylalanine + 4a-hydroxytetrahydrobiopterin + H2O
-
?

Synonyms

Synonyms Comment Organism
tyrosine hydroxylase
-
Mus musculus

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
assay at Mus musculus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.4
-
assay at Mus musculus

Cofactor

Cofactor Comment Organism Structure
tetrahydrobiopterin
-
Mus musculus