Literature summary for 1.14.16.2 extracted from

Rao, F.; Zhang, L.; Wessel, J.; Zhang, K.; Wen, G.; Kennedy, B.P.; Rana, B.K.; Das, M.; Rodriguez-Flores, J.L.; Smith, D.W.; Cadman, P.E.; Salem, R.M.; Mahata, S.K.; Schork, N.J.; Taupenot, L.; Ziegler, M.G.; OConnor, D.T.
Tyrosine hydroxylase, the rate-limiting enzyme in catecholamine biosynthesis: discovery of common human genetic variants governing transcription, autonomic activity, and blood pressure in vivo (2007), Circulation, 116, 993-1006.

Cloned(Commentary)

Cloned (Comment)	Organism
DNA and amino acid sequence determination and analysis of wild-type enzyme and polymorphic genetic variants, expression in human chromaffin cells	Homo sapiens

Protein Variants	Comment	Organism
additional information	detection of single nucleotide polymorphisms in the local genomic region, systematic polymorphism discovery at the TH locus and analysis for contributions to sympathetic function and blood pressure, i.e. 4 common TH promoter polymorphisms C-824T, G-801C, A-581G, and G-494A, overview	Homo sapiens

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
L-tyrosine + tetrahydrobiopterin + O2	Homo sapiens	tyrosine hydroxylase is the rate-limiting enzyme in catecholamine biosynthesis	3,4-dihydroxy-L-phenylalanine + 4a-hydroxytetrahydrobiopterin + H2O	-	?

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue	Comment	Organism	Textmining

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
L-tyrosine + tetrahydrobiopterin + O2	-	Homo sapiens	3,4-dihydroxy-L-phenylalanine + 4a-hydroxytetrahydrobiopterin + H2O	-	?
L-tyrosine + tetrahydrobiopterin + O2	tyrosine hydroxylase is the rate-limiting enzyme in catecholamine biosynthesis	Homo sapiens	3,4-dihydroxy-L-phenylalanine + 4a-hydroxytetrahydrobiopterin + H2O	-	?

Synonyms	Comment	Organism
tyrosine hydroxylase	-	Homo sapiens

Cofactor	Comment	Organism	Structure
tetrahydrobiopterin	-	Homo sapiens