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Literature summary for 1.14.16.2 extracted from

  • Asmus, S.E.; Anderson, E.K.; Ball, M.W.; Barnes, B.A.; Bohnen, A.M.; Brown, A.M.; Hartley, L.J.; Lally, M.C.; Lundblad, T.M.; Martin, J.B.; Moss, B.D.; Phelps, K.D.; Phillips, L.R.; Quilligan, C.G.; Steed, R.B.; Terrell, S.L.; Warner, A.E.
    Neurochemical characterization of tyrosine hydroxylase-immunoreactive interneurons in the developing rat cerebral cortex (2008), Brain Res., 1222, 95-105.
    View publication on PubMedView publication on EuropePMC

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
L-tyrosine + tetrahydrobiopterin + O2 Rattus norvegicus
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3,4-dihydroxy-L-phenylalanine + 4a-hydroxytetrahydrobiopterin + H2O
-
?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
phosphoprotein the enzyme is regulated by phosphorylation of Ser19, Ser31, and Ser40, overview Rattus norvegicus

Source Tissue

Source Tissue Comment Organism Textmining
cerebral cortex developing, intereurons, the majority of cortical tyrosine hydroxylase cells at all ages contains phosphorylated tyrosine hydroxylase Rattus norvegicus
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additional information cortical tyrosine hydroxylase neurons colocalizes with calretinin but not with parvalbumin or somatostatin Rattus norvegicus
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neuron interneurons in developing brain tissue, complete absence of cell death markers, i.e. active caspase 3, suggests that cortical tyrosine hydroxylase-immunoreactive neurons are not a transient population of cells, overview Rattus norvegicus
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-tyrosine + tetrahydrobiopterin + O2
-
Rattus norvegicus 3,4-dihydroxy-L-phenylalanine + 4a-hydroxytetrahydrobiopterin + H2O
-
?

Synonyms

Synonyms Comment Organism
tyrosine hydroxylase
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Rattus norvegicus

Cofactor

Cofactor Comment Organism Structure
tetrahydrobiopterin
-
Rattus norvegicus