Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-tyrosine + tetrahydrobiopterin + O2 | Rattus norvegicus | - |
3,4-dihydroxy-L-phenylalanine + 4a-hydroxytetrahydrobiopterin + H2O | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
- |
- |
Posttranslational Modification | Comment | Organism |
---|---|---|
phosphoprotein | the enzyme is regulated by phosphorylation of Ser19, Ser31, and Ser40, overview | Rattus norvegicus |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
cerebral cortex | developing, intereurons, the majority of cortical tyrosine hydroxylase cells at all ages contains phosphorylated tyrosine hydroxylase | Rattus norvegicus | - |
additional information | cortical tyrosine hydroxylase neurons colocalizes with calretinin but not with parvalbumin or somatostatin | Rattus norvegicus | - |
neuron | interneurons in developing brain tissue, complete absence of cell death markers, i.e. active caspase 3, suggests that cortical tyrosine hydroxylase-immunoreactive neurons are not a transient population of cells, overview | Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-tyrosine + tetrahydrobiopterin + O2 | - |
Rattus norvegicus | 3,4-dihydroxy-L-phenylalanine + 4a-hydroxytetrahydrobiopterin + H2O | - |
? |
Synonyms | Comment | Organism |
---|---|---|
tyrosine hydroxylase | - |
Rattus norvegicus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
tetrahydrobiopterin | - |
Rattus norvegicus |