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Literature summary for 1.14.16.2 extracted from

  • Urano, F.; Hayashi, N.; Arisaka, F.; Kurita, H.; Murata, S.; Ichinose, H.
    Molecular mechanism for pterin-mediated inactivation of tyrosine hydroxylase: formation of insoluble aggregates of tyrosine hydroxylase (2006), J. Biochem., 139, 625-635.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
expression in Escherichia coli Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
(6R)-L-erythro-1',2'-dihydroxypropyltetrahydropterin 80% inhibition when the enzyme is preincubated with (6R)-L-erythro-1',2'-dihydroxypropyltetrahydropterin. Inhibition was attenuated by simultanious addition of dopamine Homo sapiens
(6S)-L-erythro-1',2'-dihydroxypropyltetrahydropterin 80% inhibition when the enzyme is preincubated with (6S)-L-erythro-1',2'-dihydroxypropyltetrahydropterin Homo sapiens
6-methyltetrahydropterin 80% inhibition when the enzyme is preincubated with 6-methyltetrahydropterin Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Purification (Commentary)

Purification (Comment) Organism
more than 90% homogeneity Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
cell culture
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-tyrosine + (6R)-L-erythro-1',2'-dihydroxypropyltetrahydropterin + O2
-
Homo sapiens ?
-
?

Synonyms

Synonyms Comment Organism
TH
-
Homo sapiens
tyrosine hydroxylase
-
Homo sapiens