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Literature summary for 1.14.16.2 extracted from
- Biochemical conservation of recombinant Drosophila tyrosine hydroxylase with its mammalian cognates (2005), Biochem. Genet., 43, 425-443.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| 1,4-dithiothreitol | 48% activity without dithiotreitol | Drosophila melanogaster |  |
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| expression Escherichia coli BL21(DE33) | Drosophila melanogaster |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 3-iodotyrosine | - |
Drosophila melanogaster | |
| alpha-methyl-p-tyrosine | - |
Drosophila melanogaster | |
| dopamine | - |
Drosophila melanogaster | |
| epinephrine | - |
Drosophila melanogaster | |
| L-Dopa | - |
Drosophila melanogaster | |
| L-phenylalanine | - |
Drosophila melanogaster | |
| norepinephrine | - |
Drosophila melanogaster | |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Fe2+ | activating | Drosophila melanogaster | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Drosophila melanogaster | - |
- |
- |
Posttranslational Modification
| Posttranslational Modification | Comment | Organism |
|---|---|---|
| phosphoprotein | the enzyme is activated by cAMP-dependent protein kinase in vitro | Drosophila melanogaster |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| cell culture | - |
Drosophila melanogaster | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| L-tyrosine + 6,7-dimethyl-2-amino-4-hydroxy-5,6,7,8-tetrahydopteridine + O2 | - |
Drosophila melanogaster | 3,4-dihydroxyphenylalanine + ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| TH | - |
Drosophila melanogaster |
| tyrosine hydroxylase | - |
Drosophila melanogaster |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 31 | - |
- |
Drosophila melanogaster |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| 6,7-dimethyl-2-amino-4-hydroxy-5,6,7,8-tetrahydopteridine | strictly requirred | Drosophila melanogaster | |
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