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Literature summary for 1.14.16.2 extracted from

  • Almas, B.; Toska, K.; Teigen, K.; Groehn, V.; Pfleiderer, W.; Martinez, A.; Flatmark, T.; Haavik, J.
    A kinetic and conformational study on the interaction of tetrahydropteridines with tyrosine hydroxylase (2000), Biochemistry, 39, 13676-13686.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
isoform 1 hTH1 and His-tagged truncated mutant, expression in Escherichia coli Homo sapiens

Crystallization (Commentary)

Crystallization (Comment) Organism
crystal structure, analysis of tetrahydropterin analogues binding to isoform hTH1 Homo sapiens

Protein Variants

Protein Variants Comment Organism
additional information truncated hTH1 isoform lacking the 150 N-terminal amino acids Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
2,4-diamino-6-dihydroxypropyl-5,6,7,8-tetrahydropterin competitive against (6R)-L-erythro-tetrahydrobiopterin Homo sapiens
5(N-phenylthiocarbamoyl)-5,6,7,8-tetrahydropterin
-
Homo sapiens
5-methyl-5,6,7,8-tetrahydropterin competitive against (6R)-L-erythro-tetrahydrobiopterin Homo sapiens
6-[2-(4-benzoylphenyl)propionyloxymethyl]-5,6,7,8-tetrahydropterin competitive against (6R)-L-erythro-tetrahydrobiopterin Homo sapiens
7-amino-3,3a,4,5-tetrahydro-8H-2-oxa-5,6,8,9b-tetraaza-cyclopenta[a]naphthalene-1,9-dione competitive against (6R)-L-erythro-tetrahydrobiopterin Homo sapiens
8-methyl-6,7-dimethyl-5,6,7,8-tetrahydropterin competitive against (6R)-L-erythro-tetrahydrobiopterin Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
additional information
-
additional information Km-values of diverse tetrahydropterin analogues, substituted at C6, C7 or C3 Homo sapiens

Metals/Ions

Metals/Ions Comment Organism Structure
Iron
-
Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
isoform 1 hTH1
-

Reaction

Reaction Comment Organism Reaction ID
L-tyrosine + a 5,6,7,8-tetrahydropteridine + O2 = L-dopa + a 4a-hydroxy-5,6,7,8-tetrahydropteridine ligand binding model, hTH1 Homo sapiens

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
1
-
about, purified recombinant enzyme Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-tyrosine + (6R)-L-erythro-tetrahydrobiopterin + O2 recombinant hTH1 Homo sapiens ?
-
?
L-tyrosine + 2-methyl-4-oxo-5,6,7,8-tetrahydropterin + O2 recombinant hTH1 Homo sapiens ?
-
?
L-tyrosine + tetrahydrobiopterin + O2 recombinant hTH1 Homo sapiens 3,4-dihydroxy-L-phenylalanine + dihydrobiopterin + H2O 3,4-dihydroxy-L-phenylalanine is identical with dopa ?
additional information active with diverse tetrahydropterin analogues, substituted at C6, C7 or C3, overview Homo sapiens ?
-
?

Synonyms

Synonyms Comment Organism
TH
-
Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
25
-
recombinant hTH1, assay at Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7
-
recombinant hTH1, assay at Homo sapiens

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.001
-
6-[2-(4-benzoylphenyl)propionyloxymethyl]-5,6,7,8-tetrahydropterin
-
Homo sapiens
0.016
-
2,4-diamino-6-dihydroxypropyl-5,6,7,8-tetrahydropterin
-
Homo sapiens
0.063
-
5-methyl-5,6,7,8-tetrahydropterin
-
Homo sapiens
0.138
-
7-amino-3,3a,4,5-tetrahydro-8H-2-oxa-5,6,8,9b-tetraaza-cyclopenta[a]naphthalene-1,9-dione
-
Homo sapiens
0.617
-
8-methyl-6,7-dimethyl-5,6,7,8-tetrahydropterin
-
Homo sapiens
2.83
-
5(N-phenylthiocarbamoyl)-5,6,7,8-tetrahydropterin
-
Homo sapiens