Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
- |
- |
Purification (Comment) | Organism |
---|---|
recombinant | Rattus norvegicus |
Reaction | Comment | Organism | Reaction ID |
---|---|---|---|
L-tyrosine + a 5,6,7,8-tetrahydropteridine + O2 = L-dopa + a 4a-hydroxy-5,6,7,8-tetrahydropteridine | mechanism | Rattus norvegicus |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
4-bromo-L-phenylalanine + 6-methyltetrahydropterin + O2 | low activity | Rattus norvegicus | ? | - |
? | |
4-chloro-L-phenylalanine + 6-methyltetrahydropterin + O2 | - |
Rattus norvegicus | ? | - |
? | |
4-fluoro-L-phenylalanine + 6-methyltetrahydropterin + O2 | - |
Rattus norvegicus | ? | - |
? | |
4-methoxy-L-phenylalanine + 6-methyltetrahydropteridine + O2 | - |
Rattus norvegicus | ? | - |
? | |
4-methyl-L-phenylalanine + 6-methyltetrahydropterin + O2 | - |
Rattus norvegicus | ? | - |
? | |
L-phenylalanine + tetrahydropteridine + 2 O2 | - |
Rattus norvegicus | 3,4-dihydroxy-L-phenylalanine + dihydropteridine + 2 H2O | - |
? | |
L-tyrosine + 6-methyltetrahydropterin + O2 | - |
Rattus norvegicus | ? | - |
? | |
L-tyrosine + tetrahydrobiopterin + O2 | - |
Rattus norvegicus | 3,4-dihydroxy-L-phenylalanine + dihydrobiopterin + H2O | 3,4-dihydroxy-L-phenylalanine is identical with dopa | ? | |
additional information | 4-substituted substrate analogues get hydroxylated at position 4 or 3, the latter is preferred with big-sized substituents, multiply hydroxylated products occur as well | Rattus norvegicus | ? | - |
? |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
25 | - |
assay at | Rattus norvegicus |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.1 | - |
assay at | Rattus norvegicus |