Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 1.14.16.2 extracted from

  • Tank, A.W.; Weiner, N.
    Tyrosine 3-monooxygenase from rat pheochromocytoma (1987), Methods Enzymol., 142, 71-82.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
heparin 0.1 mg/ml, activates Rattus norvegicus
additional information activation by phosphorylation Rattus norvegicus
phosphatidylinositol 0.1 mg/ml activates Rattus norvegicus
SDS 0.01%, activates Rattus norvegicus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
additional information
-
additional information phosphorylation converts the enzyme from a form possessing a high Km for pterin cofactor to a form with a low Km for pterin cofactor Rattus norvegicus
additional information
-
additional information rat brain: 2 kinetically distinguishable forms: low Km form, high Km form Rattus norvegicus
0.075
-
tyrosine with 6-methyltetrahydropterin Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
Rattus norvegicus 5829
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
56000
-
4 * 56000, about, pheochromocytoma tumor, SDS-PAGE and amino acid sequence analysis Rattus norvegicus
225000
-
pheochromocytoma tumors, asymmetric protein, native PAGE, gel filtration and sucrose density gradient centrifugation Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
L-tyrosine + (6R)-L-erythro-1',2'-dihydroxypropyltetrahydropterin + O2 Rattus norvegicus first step in biosynthesis of catecholamines such as norepinephrine, epinephrine and dopamine ?
-
?
L-tyrosine + tetrahydrobiopterin + O2 Rattus norvegicus first step in biosynthesis of catecholamines such as norepinephrine, epinephrine and dopamine 3,4-dihydroxy-L-phenylalanine + dihydrobiopterin + H2O
-
?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
Rattus norvegicus

Source Tissue

Source Tissue Comment Organism Textmining
pheochromocytoma cell tumor Rattus norvegicus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
330
-
purified enzyme Rattus norvegicus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-tyrosine + (6R)-L-erythro-1',2'-dihydroxypropyltetrahydropterin + O2 first step in biosynthesis of catecholamines such as norepinephrine, epinephrine and dopamine Rattus norvegicus ?
-
?
L-tyrosine + 2-amino-4-hydroxy-6,7-dimethyltetrahydropterin + O2 synthetic pterin as electron donor Rattus norvegicus ?
-
?
L-tyrosine + 2-amino-4-hydroxy-6-methyltetrahydropterin + O2 synthetic pterin as electron donor Rattus norvegicus ?
-
?
L-tyrosine + 6-methyltetrahydropterin + O2
-
Rattus norvegicus ?
-
?
L-tyrosine + tetrahydrobiopterin + O2
-
Rattus norvegicus 3,4-dihydroxy-L-phenylalanine + dihydrobiopterin + H2O 3,4-dihydroxy-L-phenylalanine is identical with dopa ?
L-tyrosine + tetrahydrobiopterin + O2 first step in biosynthesis of catecholamines such as norepinephrine, epinephrine and dopamine Rattus norvegicus 3,4-dihydroxy-L-phenylalanine + dihydrobiopterin + H2O
-
?

Subunits

Subunits Comment Organism
tetramer 4 * 56000, about, pheochromocytoma tumor, SDS-PAGE and amino acid sequence analysis Rattus norvegicus

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
assay at Rattus norvegicus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
6.2
-
-
Rattus norvegicus