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Literature summary for 1.14.16.2 extracted from

  • Ikeda, M.; Levitt, M.; Udenfriend, S.
    Phenylalanine as substrate and inhibitor of tyrosine hydroxylase (1967), Arch. Biochem. Biophys., 120, 420-427.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
phenylalanine
-
Bos taurus
phenylalanine
-
Canis lupus familiaris
phenylalanine
-
Cavia porcellus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.05
-
tyrosine bovine adrenal gland Bos taurus
0.3
-
phenylalanine bovine adrenal Bos taurus

Organism

Organism UniProt Comment Textmining
Bos taurus
-
-
-
Canis lupus familiaris
-
-
-
Cavia porcellus
-
-
-

Reaction

Reaction Comment Organism Reaction ID
L-tyrosine + a 5,6,7,8-tetrahydropteridine + O2 = L-dopa + a 4a-hydroxy-5,6,7,8-tetrahydropteridine mechanism Cavia porcellus
L-tyrosine + a 5,6,7,8-tetrahydropteridine + O2 = L-dopa + a 4a-hydroxy-5,6,7,8-tetrahydropteridine mechanism Bos taurus
L-tyrosine + a 5,6,7,8-tetrahydropteridine + O2 = L-dopa + a 4a-hydroxy-5,6,7,8-tetrahydropteridine mechanism Canis lupus familiaris

Source Tissue

Source Tissue Comment Organism Textmining
adrenal gland
-
Cavia porcellus
-
adrenal gland
-
Bos taurus
-
adrenal gland
-
Canis lupus familiaris
-
caudate nucleus
-
Bos taurus
-
caudate nucleus
-
Canis lupus familiaris
-
heart
-
Cavia porcellus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-phenylalanine + tetrahydropteridine + 2 O2
-
Cavia porcellus 3,4-dihydroxy-L-phenylalanine + dihydropteridine + 2 H2O
-
?
L-phenylalanine + tetrahydropteridine + 2 O2
-
Bos taurus 3,4-dihydroxy-L-phenylalanine + dihydropteridine + 2 H2O
-
?
L-phenylalanine + tetrahydropteridine + 2 O2
-
Canis lupus familiaris 3,4-dihydroxy-L-phenylalanine + dihydropteridine + 2 H2O
-
?
L-phenylalanine + tetrahydropteridine + O2
-
Cavia porcellus L-tyrosine + dihydropteridine + H2O
-
?
L-phenylalanine + tetrahydropteridine + O2
-
Bos taurus L-tyrosine + dihydropteridine + H2O
-
?
L-phenylalanine + tetrahydropteridine + O2
-
Canis lupus familiaris L-tyrosine + dihydropteridine + H2O
-
?
L-tyrosine + tetrahydrobiopterin + O2
-
Cavia porcellus 3,4-dihydroxy-L-phenylalanine + dihydrobiopterin + H2O 3,4-dihydroxy-L-phenylalanine is identical with dopa ?
L-tyrosine + tetrahydrobiopterin + O2
-
Bos taurus 3,4-dihydroxy-L-phenylalanine + dihydrobiopterin + H2O 3,4-dihydroxy-L-phenylalanine is identical with dopa ?
L-tyrosine + tetrahydrobiopterin + O2
-
Canis lupus familiaris 3,4-dihydroxy-L-phenylalanine + dihydrobiopterin + H2O 3,4-dihydroxy-L-phenylalanine is identical with dopa ?