Cloned (Comment) | Organism |
---|---|
expressed in COS-7 cells | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
A300S | the mutant shows 31% activity compared to the wild type enzyme | Homo sapiens |
E178G | the mutant shows 39% activity compared to the wild type enzyme | Homo sapiens |
E178G/Q232E | the mutant shows 55% activity compared to the wild type enzyme | Homo sapiens |
E390G | the mutant shows 62% activity compared to the wild type enzyme | Homo sapiens |
E390G/R261Q | the mutant shows 63% activity compared to the wild type enzyme | Homo sapiens |
I65T | the mutant shows 33% activity compared to the wild type enzyme | Homo sapiens |
I65T/R261Q | the mutant shows 19.5% activity compared to the wild type enzyme | Homo sapiens |
I65T/R408W | the mutant shows 15% activity compared to the wild type enzyme | Homo sapiens |
L48S | the mutant shows 39% activity compared to the wild type enzyme | Homo sapiens |
L48S/R261Q | the mutant shows 35% activity compared to the wild type enzyme | Homo sapiens |
P384S | the mutant shows 76% activity compared to the wild type enzyme | Homo sapiens |
P384S/R408W | the mutant shows 56.1% activity compared to the wild type enzyme | Homo sapiens |
Q232E | the mutant shows 42% activity compared to the wild type enzyme | Homo sapiens |
R158Q | the mutant shows 10% activity compared to the wild type enzyme | Homo sapiens |
R158Q/R261Q | the mutant shows 23% activity compared to the wild type enzyme | Homo sapiens |
R261Q | the mutant shows 44% activity compared to the wild type enzyme | Homo sapiens |
R408Q | the mutant shows 46% activity compared to the wild type enzyme | Homo sapiens |
R408W | the mutant shows 2% activity compared to the wild type enzyme | Homo sapiens |
R408W/A300S | the mutant shows 18% activity compared to the wild type enzyme | Homo sapiens |
R408W/R158Q | the mutant shows 4% activity compared to the wild type enzyme | Homo sapiens |
R408W/R261Q | the mutant shows 18% activity compared to the wild type enzyme | Homo sapiens |
R408W/Y414C | the mutant shows 40% activity compared to the wild type enzyme | Homo sapiens |
V245A | the mutant shows 50% activity compared to the wild type enzyme | Homo sapiens |
V245A/R261Q | the mutant shows 55% activity compared to the wild type enzyme | Homo sapiens |
Y414C | the mutant shows 57% activity compared to the wild type enzyme | Homo sapiens |
Y414C/R261Q | the mutant shows 64% activity compared to the wild type enzyme | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-phenylalanine + tetrahydrobiopterin + O2 | Homo sapiens | - |
L-tyrosine + 4a-hydroxytetrahydrobiopterin | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P00439 | - |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-phenylalanine + tetrahydrobiopterin + O2 | - |
Homo sapiens | L-tyrosine + 4a-hydroxytetrahydrobiopterin | - |
? |
Synonyms | Comment | Organism |
---|---|---|
PAH | - |
Homo sapiens |
phenylalanine hydroxylase | - |
Homo sapiens |