Cloned (Comment) | Organism |
---|---|
expressed in Escherichia coli BW25113DELTAtnaA cells | Pseudomonas fluorescens |
expressed in Escherichia coli BW25113DELTAtnaA cells | Pseudomonas aeruginosa |
expressed in Escherichia coli BW25113DELTAtnaA cells | Pseudomonas putida |
expressed in Escherichia coli BW25113DELTAtnaA cells | Cupriavidus necator |
expressed in Escherichia coli BW25113DELTAtnaA cells | Xanthomonas campestris |
Protein Variants | Comment | Organism |
---|---|---|
G46S | the mutant shows lower allosteric Phe-binding ability compared to the wild type enzyme | Homo sapiens |
W179/L98Y | the mutant shows 46% activity with L-phenylalanine and 1207% activity with L-tryptophan compared to the wild type enzyme | Xanthomonas campestris |
W179F | the mutant shows 80% activity with L-phenylalanine and 1739% activity with L-tryptophan compared to the wild type enzyme | Xanthomonas campestris |
W179F/L98Y/Y231C | the mutant shows 17% activity with L-phenylalanine and 570% activity with L-tryptophan compared to the wild type enzyme | Xanthomonas campestris |
W179F/Y231C | the mutant shows 52% activity with L-phenylalanine and 952% activity with L-tryptophan compared to the wild type enzyme | Xanthomonas campestris |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-phenylalanine + tetrahydrobiopterin + O2 | Pseudomonas fluorescens | - |
L-tyrosine + 4a-hydroxytetrahydrobiopterin | - |
? | |
L-phenylalanine + tetrahydrobiopterin + O2 | Pseudomonas aeruginosa | - |
L-tyrosine + 4a-hydroxytetrahydrobiopterin | - |
? | |
L-phenylalanine + tetrahydrobiopterin + O2 | Pseudomonas putida | - |
L-tyrosine + 4a-hydroxytetrahydrobiopterin | - |
? | |
L-phenylalanine + tetrahydrobiopterin + O2 | Cupriavidus necator | - |
L-tyrosine + 4a-hydroxytetrahydrobiopterin | - |
? | |
L-phenylalanine + tetrahydrobiopterin + O2 | Xanthomonas campestris | - |
L-tyrosine + 4a-hydroxytetrahydrobiopterin | - |
? | |
L-phenylalanine + tetrahydrobiopterin + O2 | Homo sapiens | - |
L-tyrosine + 4a-hydroxytetrahydrobiopterin | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Cupriavidus necator | - |
- |
- |
Homo sapiens | P00439 | - |
- |
Pseudomonas aeruginosa | - |
- |
- |
Pseudomonas fluorescens | - |
- |
- |
Pseudomonas putida | - |
- |
- |
Xanthomonas campestris | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-phenylalanine + tetrahydrobiopterin + O2 | - |
Pseudomonas fluorescens | L-tyrosine + 4a-hydroxytetrahydrobiopterin | - |
? | |
L-phenylalanine + tetrahydrobiopterin + O2 | - |
Pseudomonas aeruginosa | L-tyrosine + 4a-hydroxytetrahydrobiopterin | - |
? | |
L-phenylalanine + tetrahydrobiopterin + O2 | - |
Pseudomonas putida | L-tyrosine + 4a-hydroxytetrahydrobiopterin | - |
? | |
L-phenylalanine + tetrahydrobiopterin + O2 | - |
Cupriavidus necator | L-tyrosine + 4a-hydroxytetrahydrobiopterin | - |
? | |
L-phenylalanine + tetrahydrobiopterin + O2 | - |
Xanthomonas campestris | L-tyrosine + 4a-hydroxytetrahydrobiopterin | - |
? | |
L-phenylalanine + tetrahydrobiopterin + O2 | - |
Homo sapiens | L-tyrosine + 4a-hydroxytetrahydrobiopterin | - |
? | |
L-phenylalanine + tetrahydrobiopterin + O2 | preferred substrate | Pseudomonas fluorescens | L-tyrosine + 4a-hydroxytetrahydrobiopterin | - |
? | |
L-phenylalanine + tetrahydrobiopterin + O2 | preferred substrate | Pseudomonas aeruginosa | L-tyrosine + 4a-hydroxytetrahydrobiopterin | - |
? | |
L-phenylalanine + tetrahydrobiopterin + O2 | preferred substrate | Pseudomonas putida | L-tyrosine + 4a-hydroxytetrahydrobiopterin | - |
? | |
L-phenylalanine + tetrahydrobiopterin + O2 | preferred substrate | Cupriavidus necator | L-tyrosine + 4a-hydroxytetrahydrobiopterin | - |
? | |
L-phenylalanine + tetrahydrobiopterin + O2 | preferred substrate | Xanthomonas campestris | L-tyrosine + 4a-hydroxytetrahydrobiopterin | - |
? | |
L-tryptophan + tetrahydrobiopterin + O2 | - |
Pseudomonas fluorescens | 5-hydroxytryptophan + 4a-hydroxytetrahydrobiopterin | - |
? | |
L-tryptophan + tetrahydrobiopterin + O2 | - |
Pseudomonas aeruginosa | 5-hydroxytryptophan + 4a-hydroxytetrahydrobiopterin | - |
? | |
L-tryptophan + tetrahydrobiopterin + O2 | - |
Pseudomonas putida | 5-hydroxytryptophan + 4a-hydroxytetrahydrobiopterin | - |
? | |
L-tryptophan + tetrahydrobiopterin + O2 | - |
Cupriavidus necator | 5-hydroxytryptophan + 4a-hydroxytetrahydrobiopterin | - |
? | |
L-tryptophan + tetrahydrobiopterin + O2 | - |
Xanthomonas campestris | 5-hydroxytryptophan + 4a-hydroxytetrahydrobiopterin | - |
? |
Subunits | Comment | Organism |
---|---|---|
homotetramer | - |
Homo sapiens |
Synonyms | Comment | Organism |
---|---|---|
P4H | - |
Pseudomonas fluorescens |
P4H | - |
Pseudomonas aeruginosa |
P4H | - |
Pseudomonas putida |
P4H | - |
Cupriavidus necator |
P4H | - |
Xanthomonas campestris |
PAH | - |
Homo sapiens |
phenylalanine 4-hydroxylase | - |
Pseudomonas fluorescens |
phenylalanine 4-hydroxylase | - |
Pseudomonas aeruginosa |
phenylalanine 4-hydroxylase | - |
Pseudomonas putida |
phenylalanine 4-hydroxylase | - |
Cupriavidus necator |
phenylalanine 4-hydroxylase | - |
Xanthomonas campestris |
phenylalanine hydroxylase | - |
Pseudomonas fluorescens |
phenylalanine hydroxylase | - |
Pseudomonas aeruginosa |
phenylalanine hydroxylase | - |
Pseudomonas putida |
phenylalanine hydroxylase | - |
Cupriavidus necator |
phenylalanine hydroxylase | - |
Xanthomonas campestris |
phenylalanine hydroxylase | - |
Homo sapiens |
phhA | - |
Pseudomonas fluorescens |
phhA | - |
Pseudomonas aeruginosa |
phhA | - |
Pseudomonas putida |
phhA | - |
Cupriavidus necator |
phhA | - |
Xanthomonas campestris |