KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.001 | - |
5,6,7,8-tetrahydrobiopterin | using L-phenylalanine as cosubstrate | Mus musculus | |
0.04 | - |
L-phenylalanine | using 5,6,7,8-tetrahydrobiopterin as cofactor | Mus musculus | |
0.043 | - |
6-methyltetrahydropterin | using L-phenylalanine as cosubstrate | Mus musculus | |
0.25 | - |
L-phenylalanine | using 6-methyltetrahydropterin as cofactor | Mus musculus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
liver | - |
Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-phenylalanine + 5,6,7,8-tetrahydrobiopterin + O2 | - |
Mus musculus | L-tyrosine + 4a-hydroxytetrahydrobiopterin | - |
? | |
L-phenylalanine + 6-methyltetrahydropterin + O2 | - |
Mus musculus | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
PAH | - |
Mus musculus |
phenylalanine hydroxylase | - |
Mus musculus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
5,6,7,8-tetrahydro-L-biopterin | PAH can be activated up to 20times in the presence of its natural cofactor 5,6,7,8-tetrahydro-L-biopterin but cannot be activated in the presence of synthetic cofactors such as 6,7-dimethyltetrahydrobiopterin or 6-methyltetrahydropterin | Mus musculus |