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Literature summary for 1.14.16.1 extracted from
- Connecting mutant phenylalanine hydroxylase with phenylketonuria (2008), J. Clin. Monit. Comput., 22, 333-342.
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| additional information | calculation and computational modeling of the probability that a mutation or an amino acid change in certain positions lead to phenylketonuria to improve clinical monitoring, diagnosis, prognosis and treatment, overview | Homo sapiens |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| L-phenylalanine + tetrahydrobiopterin + O2 | Homo sapiens | enzyme mutations can lead to phenylketonuria, overview | L-tyrosine + 4a-hydroxytetrahydrobiopterin | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | P00439 | - |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| L-phenylalanine + tetrahydrobiopterin + O2 | - |
Homo sapiens | L-tyrosine + 4a-hydroxytetrahydrobiopterin | - |
? | |
| L-phenylalanine + tetrahydrobiopterin + O2 | enzyme mutations can lead to phenylketonuria, overview | Homo sapiens | L-tyrosine + 4a-hydroxytetrahydrobiopterin | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| phenylalanine hydroxylase | - |
Homo sapiens |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| tetrahydrobiopterin | - |
Homo sapiens | |
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Release 2023.1 (January 2023)
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