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Literature summary for 1.14.16.1 extracted from

  • Goreish, A.H.; Bednar, S.; Jones, H.; Mitchell, S.C.; Steventon, G.B.
    Phenylalanine 4-monooxygenase and the S-oxidation of S-carboxymethyl-L-cysteine (2004), Drug Metabol. Drug Interact., 20, 159-174.
    View publication on PubMed
Search for more literature for 1.14.16.1

Inhibitors

Inhibitors Comment Organism Structure
deferoxamine 5 mM, 1% residual activity Rattus norvegicus
L-methionine 5 mM, 55% residual activity with substrate L-phenylalanine Rattus norvegicus
L-phenylalanine competitive Rattus norvegicus
S-carboxymethyl-L-cysteine competitive to L-phenylalanine, 5 mM, 74% residual activity with substrate L-phenylalanine Rattus norvegicus
S-methyl-L-cysteine competitive to L-phenylalanine, 5 mM, 89% residual activity with substrate L-phenylalanine Rattus norvegicus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.00936
-
 tetrahydrobiopterin pH 6.8, 37°C, cosubstrate L-phenylalanine Rattus norvegicus
0.26
-
 L-phenylalanine pH 6.8, 37°C Rattus norvegicus
14.73
-
 S-carboxymethyl-L-cysteine pH 6.8, 37°C Rattus norvegicus
43.25
-
 S-methyl-L-cysteine pH 6.8, 37°C Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
 Rattus norvegicus 5829
-

Metals/Ions

Metals/Ions Comment Organism Structure
Iron
-
 Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
 Wistar
-
Rattus norvegicus Wistar
-
 Wistar
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-phenylalanine + tetrahydrobiopterin + O2
-
 Rattus norvegicus L-tyrosine + dihydrobiopterin + H2O
-
 ?
L-phenylalanine + tetrahydrobiopterin + O2
-
 Rattus norvegicus Wistar L-tyrosine + dihydrobiopterin + H2O
-
 ?
S-carboxymethyl-L-cysteine + tetrahydrobiopterin + O2
-
 Rattus norvegicus S-carboxymethyl-L-cysteine S-oxide + dihydrobiopterin + H2O
-
 ?
S-carboxymethyl-L-cysteine + tetrahydrobiopterin + O2
-
 Rattus norvegicus Wistar S-carboxymethyl-L-cysteine S-oxide + dihydrobiopterin + H2O
-
 ?
S-methyl-L-cysteine + tetrahydrobiopterin + O2
-
 Rattus norvegicus S-methyl-L-cysteine S-oxide + dihydrobiopterin + H2O
-
 ?
S-methyl-L-cysteine + tetrahydrobiopterin + O2
-
 Rattus norvegicus Wistar S-methyl-L-cysteine S-oxide + dihydrobiopterin + H2O
-
 ?