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Literature summary for 1.14.16.1 extracted from

  • Doeskeland, A.P.; Martinez, A.; Knappskog, P.M.; Flatmark, T.
    Phosphorylation of recombinant human phenylalanine hydroxylase: effect on catalytic activity, substrate activation and protection against non-specific cleavage of the fusion protein by restriction protease (1996), Biochem. J., 313, 409-414.
No PubMed abstract available

Activating Compound

Activating Compound Comment Organism Structure
cAMP-dependent protein kinase 1.6fold increase in activity, cofactor tetrahydrobiopterin Homo sapiens
phenylalanine approx. 4.5fold increase in activity of non-phosphorylated and phosphorylated enzyme, cofactor tetrahydrobiopterin Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
-
Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
side-chain modification recombinant enzyme incorporates 1 mol phosphate per mol of enzyme subunit when phosphorylated in vitro by cyclic AMP-dependent protein kinase, Ser-16 seems to be the phosphorylation site Homo sapiens