Literature summary for 1.14.16.1 extracted from

Martinez, A.; Olafsdottir, S.; Haavik, J.; Flatmark, T.
Inactivation of purified phenylalanine hydroxylase by dithiothreitol (1992), Biochem. Biophys. Res. Commun., 182, 92-98.

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Inhibitors

Inhibitors	Comment	Organism	Structure
2-mercaptoethanol	2 mM, 80% inhibition	Rattus norvegicus
ascorbate	2 mM, 78% inhibition	Rattus norvegicus
dithiothreitol	2 mM, 94% inhibition, dithiothreitol induces the dissociation of iron from the enzyme, catalase and phenylalanine partially protect from inhibition	Rattus norvegicus
L-cysteine	2 mM, 42% inhibition	Rattus norvegicus

Metals/Ions

Metals/Ions	Comment	Organism	Structure
Iron	1 iron atom per subunit, fully active enzyme has non-heme high-spin ferric iron coordinated at the active site	Rattus norvegicus

Organism

Organism	UniProt	Comment	Textmining
Rattus norvegicus	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
liver	-	Rattus norvegicus	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
L-phenylalanine + tetrahydrobiopterin + O2	-	Rattus norvegicus	L-tyrosine + dihydrobiopterin + H2O	-	?

Cofactor

Cofactor	Comment	Organism	Structure
tetrahydrobiopterin	-	Rattus norvegicus

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Release 2023.1 (January 2023)