Literature summary for 1.14.16.1 extracted from

Koizumi, S.; Matsushima, Y.; Nagatsu, T.; Linuma, H.; Takeuchi, T.; Umezawa, H.
3,4-Dihydroxystyrene, a novel microbial inhibitor for phenylalanine hydroxylase and other pteridine-dependent monooxygenases (1984), Biochim. Biophys. Acta, 789, 111-118.

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Inhibitors

Inhibitors	Comment	Organism	Structure
3,4-dihydroxyphenylpropane	0.0016 mM, 50% inhibition	Rattus norvegicus
3,4-Dihydroxyphenylpropionic acid	0.24 mM, 50% inhibition	Rattus norvegicus
3,4-Dihydroxystyrene	0.0005-0.005 mM, 50% inhibition, noncompetitive vs. 6,7-dimethyltetrahydropterin and L-phenylalanine	Rattus norvegicus
catechol	0.033 mM, 50% inhibition	Rattus norvegicus
dopamine	0.025 mM, 50% inhibition	Rattus norvegicus

Organism

Organism	UniProt	Comment	Textmining
Rattus norvegicus	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
liver	-	Rattus norvegicus	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
L-phenylalanine + tetrahydrobiopterin + O2	-	Rattus norvegicus	L-tyrosine + dihydrobiopterin + H2O	-	?

Cofactor

Cofactor	Comment	Organism	Structure
tetrahydrobiopterin	-	Rattus norvegicus

Ki Value [mM]

Ki Value [mM]	Ki Value maximum [mM]	Inhibitor	Comment	Organism	Structure
0.00027	-	3,4-Dihydroxystyrene	with 15 min preincubation	Rattus norvegicus
0.0032	-	3,4-Dihydroxystyrene	without preincubation	Rattus norvegicus

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Release 2023.1 (January 2023)