Cloned (Comment) | Organism |
---|---|
expression in Escherichia coli | Priestia megaterium |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Priestia megaterium | - |
- |
- |
Priestia megaterium | Q06069 | isoform Cyp106A2 | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
11-deoxycorticosterone + reduced adrenodoxin + O2 | - |
Priestia megaterium | 15beta-hydroxy-11-deoxycorticosterone + 7beta,15beta-dihydroxy-11-deoxycorticosterone + oxidized adrenodoxin + H2O | - |
? | |
11-deoxycortisol + reduced adrenodoxin + O2 | - |
Priestia megaterium | 15beta-hydroxy-11-deoxycortisol + oxidized adrenodoxin + H2O | - |
? | |
11beta-hydroxy-4-androstene-3,17-dione + reduced adrenodoxin + O2 | - |
Priestia megaterium | ? + oxidized adrenodoxin + H2O | - |
? | |
17alpha-methyltestosterone + reduced adrenodoxin + O2 | - |
Priestia megaterium | ? + oxidized adrenodoxin + H2O | - |
? | |
19-nortestosterone + reduced adrenodoxin + O2 | - |
Priestia megaterium | ? + oxidized adrenodoxin + H2O | - |
? | |
4-androstene-3,17-dione + reduced adrenodoxin + O2 | - |
Priestia megaterium | 15beta-hydroxyandrostene-3,17-dione + oxidized adrenodoxin + H2O | - |
? | |
corticosterone + reduced adrenodoxin + O2 | - |
Priestia megaterium | 15beta-hydroxycorticosterone + oxidized adrenodoxin + H2O | - |
? | |
cortisone + reduced adrenodoxin + O2 | - |
Priestia megaterium | 15beta-hydroxycortisone + oxidized adrenodoxin + H2O | - |
? | |
dexamethasone + reduced adrenodoxin + O2 | - |
Priestia megaterium | ? + oxidized adrenodoxin + H2O | - |
? | |
additional information | enzyme produces hydroxylated metabolites at positions 6beta, 7beta, 9alpha, and 15beta and shows additionally 11-oxidase activity. No substrates: beta-estradiol, estrone, adrenosterone, and 19-hydroxyandrostenedione | Priestia megaterium | ? | - |
? | |
additional information | enzyme produces hydroxylated metabolites at positions 6beta, 7beta, 9alpha,and 15beta and shows additionally 11-oxidase activity. No substrates: beta-estradiol, estrone, adrenosterone, and 19-hydroxyandrostenedione | Priestia megaterium | ? | - |
? | |
prednisolone + reduced adrenodoxin + O2 | - |
Priestia megaterium | ? + oxidized adrenodoxin + H2O | - |
? | |
prednisone + reduced adrenodoxin + O2 | - |
Priestia megaterium | ? + oxidized adrenodoxin + H2O | - |
? | |
testosterone + reduced adrenodoxin + O2 | - |
Priestia megaterium | 15beta-hydroxytestosterone + oxidized adrenodoxin + H2O | - |
? |
Synonyms | Comment | Organism |
---|---|---|
Cyp106A1 | - |
Priestia megaterium |
CYP106A2 | - |
Priestia megaterium |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
heme | steroids beta-estradiol, estrone, pregnenolone and 17alpha-hydroxypregnenolone, do not shift the heme iron into the high-spin form | Priestia megaterium |