Literature summary for 1.14.15.6 extracted from

Cook, J.B.; Werner, D.F.; Maldonado-Devincci, A.M.; Leonard, M.N.; Fisher, K.R.; OBuckley, T.K.; Porcu, P.; McCown, T.J.; Besheer, J.; Hodge, C.W.; Morrow, A.L.
Overexpression of the steroidogenic enzyme cytochrome P450 side chain cleavage in the ventral tegmental area increases 3alpha,5alpha-THP and reduces long-term operant ethanol self-administration (2014), J. Neurosci., 34, 5824-5834 .

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Application

Application	Comment	Organism
medicine	P450scc overexpression in the ventral tegmental area significantly reduces ethanol self-administration of alcohol preferring rats trained to self-administer ethanol, by 20% over the 3 week test period. P450scc overexpression in the nucleus accumbens, does not alter ethanol self-administration. P450scc overexpression produces a 36% increase in (3alpha,5alpha)-3-hydroxypregnan-20-one-positive cells in the ventral tegmental area, but does not increase (3alpha,5alpha)-3-hydroxypregnan-20-one immunoreactivity in nucleus accumbens	Rattus norvegicus

Cloned(Commentary)

Cloned (Comment)	Organism
expression in the ventral tegmental area or nucleus accumbens of rat	Rattus norvegicus

Organism

Organism	UniProt	Comment	Textmining
Rattus norvegicus	P14137	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
olfactory bulb	-	Rattus norvegicus	-

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Release 2023.1 (January 2023)