Application | Comment | Organism |
---|---|---|
analysis | examination of protein-membrane interactions between P450scc and its redox partners on 1,2-dimyristoyl-sn-glycero-3-phosphocholine membranes containing cholesterol (20%), using a quartz crystal microbalance with dissipation monitoring | Bos taurus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
membrane | - |
Bos taurus | 16020 | - |
mitochondrion | - |
Bos taurus | 5739 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Bos taurus | P00189 | - |
- |
Synonyms | Comment | Organism |
---|---|---|
P450scc | - |
Bos taurus |
General Information | Comment | Organism |
---|---|---|
physiological function | the activity of P450scc is dependent upon electron delivery from NADPH-dependent adrenodoxin reductase (AdR), via adrenodoxin (Adx). The lipid membrane assists in the assembly of electron transport proteins and the activity of P450scc by providing a surface for the localized concentration of proteins. Using sequential deposition with P450scc first (to saturation), there is effectively no further binding of AdR or Adx. When premixing the three proteins, P450scc, Adx and AdR, all bind the membrane in a two-stage process | Bos taurus |